{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:16:39Z","timestamp":1767611799020,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>HLA\u2010B*58:01 is a well\u2010known risk factor for allopurinol\u2010induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA\u2010B*58:01 carriers suffer SCARs after taking allopurinol. The aim of this study was to investigate subsidiary genetic markers that could identify those at further increased risk of developing allopurinol\u2010induced drug reaction with eosinophilia and systemic symptoms (DRESS) in subjects with HLA\u2010B*58:01.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects with B*58:01 were enrolled (21 allopurinol\u2010induced DRESS and 52 allopurinol\u2010tolerant control). HLA\u2010A, \u2010B, \u2010C and \u2010DRB1 alleles were compared. Comparison of risk between HLAs and allopurinol\u2010induced SCAR in separate populations was performed to support the results. Kruskal\u2010Wallis test, Pearson's chi\u2010square test, Fisher's exact test and binary logistic regression were used to analyze the risk of SCAR development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Frequencies of A*24:02 (71.4 vs. 17.3%, <jats:italic>p<\/jats:italic> &lt; 0.001, odds ratio [OR]\u00a0=\u00a012.0; 95% confidence interval [CI], 3.6\u201339.2) were significantly higher in B*58:01 (+) DRESS than B*58:01 (+) tolerant controls. In addition, DRB1*13:02 further increased the risk of DRESS. The phenotype frequency of A*24:02\/DRB1*13:02 was significantly higher in the B*58:01 (+) DRESS group than in the B*58:01 (+) tolerant controls (52.4% vs. 5.8%, <jats:italic>p<\/jats:italic> &lt; 0.001, OR, 66.0; 95% CI, 6.1\u2013716.2). In 2782 allopurinol user cohort, the overall prevalence of DRESS was 0.22%, which increased to 1.62% and 2.86% in the presence of B*58:01 and B*58:01\/A*24:02, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The additional secondary screening with A*24:02 and DRB1*13:02 alleles may identify those at further increased risk of allopurinol\u2010induced DRESS in B*58:01 carriers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12193","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T05:44:11Z","timestamp":1663307051000},"source":"Crossref","is-referenced-by-count":7,"title":["HLA\u2010A*24:02 increase the risk of allopurinol\u2010induced drug reaction with eosinophilia and systemic symptoms in HLA\u2010B*58:01 carriers in a Korean population; a multicenter cross\u2010sectional case\u2010control study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-6258","authenticated-orcid":false,"given":"Mi\u2010Yeong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Busan Paik Hospital Inje University College of Medicine  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology Nepean Hospital The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-2633","authenticated-orcid":false,"given":"Dong\u2010Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Drug Safety Monitoring Center Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department 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Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine  Hwaseong Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Suk","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine SMG\u2010SNU Boramae Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Seok","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul 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