{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:55:02Z","timestamp":1789170902202,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Charcot\u2010Leyden crystals (CLCs) are recognized to be classic hallmarks of eosinophilic inflammation. Both protein and mRNA levels of CLC in nasal secretions and nasal brushing samples have been associated with nasal polyp recurrence. However, whether the crystalline CLC structures in nasal tissue could serve as an effective biomarker to predict polyp recurrence remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 110 patients with chronic rhinosinusitis with nasal polyps (CRSwNP) completing the postoperative follow\u2010up over a period of 24\u00a0months were recruited. Hematoxylin and eosin staining was employed for CLCs identification. The predictive factors for polyp recurrence were determined by binary logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty three (30.00%) patients developed recurrence during a 24\u2010month postoperative follow\u2010up, in which 84.85% (28\/33) patients had crystalline CLC structures. Logistic regression analysis showed that crystalline CLC structure in nasal tissues is predictive of polyp recurrence. Youden index demonstrated crystalline CLC structure higher than 1 per high power field can predict postoperative polyp recurrence with 84.80% sensitivity and 98.70% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The crystalline CLC structures in nasal tissues may serve as an easy\u2010counting and promising biomarker to predict CRSwNP recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12212","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T08:45:06Z","timestamp":1669106706000},"source":"Crossref","is-referenced-by-count":24,"title":["Predictive significance of Charcot\u2010Leyden crystal structures for nasal polyp recurrence"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenyi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Guangzhou Women and Children's Medical Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuvam","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianning","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qintai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Department of Allergy The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-2943","authenticated-orcid":false,"given":"Yana","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"e_1_2_1_8_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4231"},{"key":"e_1_2_1_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.05.004"},{"key":"e_1_2_1_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201044627\u2010z"},{"key":"e_1_2_1_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010019\u20100868\u20100"},{"key":"e_1_2_1_8_6_1","first-page":"166","article-title":"Predictive significance of Charcot\u2010Leyden crystal mRNA levels in nasal brushing for nasal polyp recurrence","volume":"58","author":"Qi S","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_1_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510120"},{"key":"e_1_2_1_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.03.029"},{"key":"e_1_2_1_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2021.03.013"},{"key":"e_1_2_1_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4295"},{"key":"e_1_2_1_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"}],"container-title":["Clinical and Translational 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