{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:14:47Z","timestamp":1790709287246,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cow's milk (CM) and hen's egg (HE) are leading triggers of anaphylaxis in early childhood. The aim of this study was to identify clinical phenotypes and therapeutic measures for CM anaphylaxis (CMA) compared to HE anaphylaxis (HEA) in children up to 12\u00a0years of age, based on a large pan\u2010European dataset from the European Anaphylaxis Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 2007 to 2020 on clinical phenotypes and treatment from 10 European countries, as well as Brazil, were analysed. The two\u2010step cluster analysis was used to identify the most frequent phenotypes. For each trigger, three clusters were extracted based on sex, age, and existence of symptoms in four vitally important systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 284 children with CMA and 200 children with HEA were identified. They were characterised as male (69% vs. 64%), infants (65% vs. 61%), with a most frequent grade III of Ring&amp;Messmer classification (62% vs. 64%), in CMA versus HEA, respectively. Respiratory symptoms occurred more often in CMA (91% vs. 83%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.010), especially in infants (89% vs. 79%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). Cardiovascular symptoms were less frequent in CMA (30% vs. 44%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), in both infants (33% vs. 46%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027), and older children (25% vs. 42%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021). The clusters extracted in the CMA group were characterised as: (1) mild dermal infants with severe GI (40%), 2. severe dermal (35%), 3. respiratory (25%). While in HEA group: 1. infants with severe GI and\/or reduction of alertness (40%), (2) conjunctival (16%), (3) mild GI without conjunctivitis (44%). The severity of the reaction was independent from the amount of ingested allergen protein, regardless of trigger. The first\u2010line adrenaline application differed between the countries (0%\u201392%, as well as the reasons for not administering adrenaline, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the similarity of their age, sex, and severity grade, the clinical profiles differed between the CMA and HEA children. Adrenaline was underused, and its administration was country dependent. Further studies are needed to assess to what extent the differences in the clinical profiles are related to matrix and\/or absorption effects, and\/or the allergen itself.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12228","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:28:23Z","timestamp":1679898503000},"source":"Crossref","is-referenced-by-count":15,"title":["Cow's milk and hen's egg anaphylaxis: A comprehensive data analysis from the European Anaphylaxis Registry"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-5976","authenticated-orcid":false,"given":"Ewa","family":"Cichocka\u2010Jarosz","sequence":"first","affiliation":[{"name":"Department of Paediatrics Pulmonology, Allergy and Dermatology Clinic Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-0709","authenticated-orcid":false,"given":"Sabine","family":"D\u00f6lle\u2010Bierke","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Jedynak\u2010W\u0105sowicz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Pulmonology, Allergy and Dermatology Clinic Jagiellonian University Medical College  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sabouraud\u2010Leclerc","sequence":"additional","affiliation":[{"name":"University Hospital Centre  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"K\u00f6hli","sequence":"additional","affiliation":[{"name":"Division of Allergology University Children's Hospital Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St. Marien\u2010Hospital  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos G.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Allergy Department 2nd Paediatric Clinic University of Athens  Athens Greece"},{"name":"Division of Infection Immunity and Respiratory Medicine University of Manchester  Manchester 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Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venerology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.11.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.048"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.020"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14464"},{"key":"e_1_2_11_6_1","article-title":"Frequency of food allergy in Europe: an updated systematic review and 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