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This study aimed to explore inflammation\u2010related plasma biomarkers in lean and overweight\/obese asthmatics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We elucidated levels of inflammation\u2010related plasma proteins in obese asthma phenotypes in the population\u2010based cohort BAMSE (Swedish: Children, Allergy, Milieu, Stockholm, Epidemiology) using data from 2069 24\u201026\u2010year\u2010olds. Subjects were divided into lean asthma (<jats:italic>n<\/jats:italic>\u00a0=\u00a0166), lean controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a01440), overweight\/obese asthma (<jats:italic>n<\/jats:italic>\u00a0=\u00a073) and overweight\/obese controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a0390). Protein levels (<jats:italic>n<\/jats:italic>\u00a0=\u00a092) were analysed using the Olink Proseek Multiplex Inflammation panel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 92 included proteins, 41 were associated with lean and\/or overweight\/obese asthma. The majority of proteins associated with overweight\/obese asthma also associated with overweight\/obesity among non\u2010asthmatics. Beta\u2010nerve growth factor (BetaNGF), interleukin 10 (IL\u201010), and matrix metalloproteinase 10 (MMP10) were associated only with lean asthma while C\u2010C motif chemokine 20 (CCL20), fibroblast growth factor 19 (FGF19), interleukin 5 (IL\u20105), leukemia inhibitory factor (LIF), tumor necrosis factor ligand superfamily member 9 (TNFRSF9), and urokinase\u2010type plasminogen activator (uPA) were associated only with overweight\/obese asthma. Overweight\/obesity modified the association between asthma and 3 of the proteins: fibroblast growth factor 21 (FGF21), interleukin 4 (IL\u20104), and urokinase\u2010type plasminogen activator (uPA). In the overweight\/obese group, interleukin\u20106 (IL\u20106) was associated with non\u2010allergic asthma but not allergic asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data indicate distinct plasma protein phenotypes in lean and overweight\/obese asthmatics which, in turn, can impact upon therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12238","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T13:33:34Z","timestamp":1679492014000},"source":"Crossref","is-referenced-by-count":19,"title":["Obese asthma phenotypes display distinct plasma biomarker profiles"],"prefix":"10.1002","volume":"13","author":[{"given":"Sophia","family":"Bj\u00f6rkander","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet  Stockholm 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