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This study assessed the minimal clinically important difference (MCID) of nasal symptom score (NSS), non\u2010nasal symptom score (NNSS), and total symptoms score (TSS) for app\u2010based hay\u2010fever monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MCIDs were calculated based on the data from a previous large\u2010scale, crowdsourced, cross\u2010sectional study using AllerSearch, an in\u2010house smartphone application. MCIDs were determined with anchor\u2010based and distribution\u2010based methods. The face scale score of the Japanese Allergic Conjunctival Disease Standard Quality of Life Questionnaire Domain III and the daily stress level due to hay fever were used as anchors for determining MCIDs. The MCID estimates were summarized as MCID ranges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7590 participants were included in the analysis (mean age: 35.3\u00a0years, 57.1% women). The anchor\u2010based method produced a range of MCID values (median, interquartile range) for NSS (2.0, 1.5\u20132.1), NNSS (1.0, 0.9\u20131.2), and TSS (2.9, 2.4\u20133.3). The distribution\u2010based method produced two MCIDs (based on half a standard deviation, based on a standard error of measurement) for NSS (2.0, 1.8), NNSS (1.3, 1.2), and TSS (3.0, 2.3). The final suggested MCID ranges for NSS, NNSS, and TSS were 1.8\u20132.1, 1.2\u20131.3, and 2.4\u20133.3, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MCID ranges for app\u2010based hay\u2010fever symptom assessment were obtained from the data collected through a smartphone application, AllerSearch. These estimates may be useful for monitoring the subjective symptoms of Japanese patients with hay fever through mobile platforms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12244","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T04:17:43Z","timestamp":1683001063000},"source":"Crossref","is-referenced-by-count":10,"title":["The minimal clinically important difference of app\u2010based electronic patient\u2010reported outcomes for hay fever"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-6074","authenticated-orcid":false,"given":"Ken","family":"Nagino","sequence":"first","affiliation":[{"name":"Department of Hospital Administration Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Ophthalmology Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Digital Medicine Juntendo University Graduate School of Medicine  Tokyo 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