{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:01:54Z","timestamp":1792180914783,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008493","name":"V\u00e4in\u00f6 ja Laina Kiven S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008368","name":"Suomen Tuberkuloosin Vastustamisyhdistyksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011824","name":"European Academy of Allergy and Clinical Immunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma with NSAID\u2010exacerbated respiratory disease (NERD) is associated with uncontrolled or severe asthma. NERD patients are more prone to severe allergic reactions and their asthma exacerbations lead to hospitalisations twice as often compared to patients with non\u2010NERD\u2010asthma. NERD patients are prone to recurrent nasal polyposis requiring frequent endoscopic sinus surgeries. However, the early risk factors of NERD are not fully understood. The aim was to identify risk factors of NERD among patients with adult\u2010onset asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from 1350 population\u2010based adult asthmatics with adult\u2010onset asthma from Finnish national registers. NERD was defined as self\u2010reported wheeze or other typical respiratory symptoms after ingestion of NSAIDs. Thirty\u2010six covariates covering several domains (personal characteristics, life\u2010style, early life factors, asthma characteristics and multimorbidities) were selected based on literature and were studied in association with NERD using logistic regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study population included 153 (11.3%) asthmatics with NERD. Thirty\u2010six covariates were entered in univariate logistic regression analysis, in which 23 were associated with NERD (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). These variables were entered in a multivariable logistic regression model in which allergic respiratory symptoms, female sex, osteoarthritis, difficult asthma, nasal polyps, second\u2010hand smoke exposure at home, having 3 or more older siblings and being overweight were significantly associated with asthma with NERD (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Overweight decreased the risk of NERD, other factors increased it.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>According to our study, risk factors of NERD in part are associated with female sex, BMI, exposure to tobacco smoke, allergy, orthopaedic disorders and infection history, and their early recognition might thus be important to manage the burden of NERD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.12296","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:30:02Z","timestamp":1692682202000},"source":"Crossref","is-referenced-by-count":7,"title":["Risk factors of NSAID\u2010exacerbated respiratory disease: A\u00a0population\u2010based study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7289-358X","authenticated-orcid":false,"given":"Alma","family":"Helev\u00e4","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Hospital District of Helsinki and Uusimaa  Helsinki Finland"},{"name":"MD PhD Programme of the Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aada","family":"Murtom\u00e4ki","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Hospital District of Helsinki and Uusimaa  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences Tampere University  Tampere 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University Hospital  Tampere Finland"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Lemmetyinen","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Hospital District of Helsinki and Uusimaa  Helsinki Finland"},{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Haukka","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Torkki","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki  Helsinki 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