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The symptoms greatly impact a patient's quality of life (QoL) and include excruciating abdominal pain and angioedema of the skin and submucosa. Angioedema of the larynx represents a significant mortality risk in undiagnosed patients, and a large proportion of patients with HAE receive incorrect diagnoses and undergo unnecessary surgery. HAE\u2010specific treatments can control and prevent acute life\u2010threatening episodes, in addition to improving QoL, emphasizing the value of early diagnosis for patients. Diagnostic delay may be due to a lack of HAE awareness by healthcare professionals and the similarity of HAE symptoms with those of more common conditions, complicating differential diagnosis. The multifaceted nature of the condition may result in visits to one of many different medical settings, for example: the Emergency Room, pediatrics, general practice, otolaryngology, gastroenterology, and dermatology. Therefore, it is crucial that physicians in multiple healthcare specialties are aware of the disease to ensure that patients with HAE receive a timely diagnosis. Using patient cases from various medical specialties, this review highlights the necessity for cross\u2010specialty awareness of HAE and outlines the essential information for the various healthcare professionals that may encounter a patient with HAE symptoms, in order to effectively treat and\/or diagnose HAE.<\/jats:p>","DOI":"10.1002\/clt2.12297","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T05:29:31Z","timestamp":1695187771000},"source":"Crossref","is-referenced-by-count":11,"title":["Could it be hereditary angioedema?\u2014Perspectives from different medical specialties"],"prefix":"10.1002","volume":"13","author":[{"given":"Markus","family":"Magerl","sequence":"first","affiliation":[{"name":"Institute of Allergology IFA Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Allergology and Immunology Berlin 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