{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:48:22Z","timestamp":1791870502721,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003031","name":"Agence de l'Environnement et de la Ma\u00eetrise de l'Energie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007241","name":"Universit\u00e9 Paris-Saclay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few population\u2010based studies have described allergic rhinitis (AR) according to the Allergic Rhinitis and its Impact on Asthma (ARIA) classification, and none have assessed the impact of asthma on this classification. Our aims were to 1) describe AR according to four ARIA classes and 2) within each of the four ARIA classes, compare participants with AR alone versus those with AR and asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional analyses were performed using data from the 2014 annual follow\u2010up questionnaire of the French adult population\u2010based cohort Constances. Current AR was defined by the report of sneezing, runny, or blocked nose in the last 12\u00a0months and the report of nasal allergies. Following ARIA recommendations, rhinitis was classified according to its severity (mild or moderate\u2010severe) and duration (intermittent or persistent). Ever asthma was also defined by a questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 4675 participants with AR (57% women, mean age 50.2\u00a0\u00b1\u00a012.7\u00a0years), 44% were classified as mild\/intermittent, 16% mild\/persistent, 25% moderate\u2010severe\/intermittent, and 15% moderate\u2010severe\/persistent. Within each of the four ARIA classes, compared to participants with rhinitis alone, participants with rhinitis and asthma had significantly more severe symptoms, more conjunctivitis, a higher mean eosinophil count and more treatments with intra\u2010nasal corticosteroids and oral antihistamines co\u2010medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is a paradigm shift study as for the first time this large population\u2010based study in adults showed that asthma status has a profound effect on the ARIA classification. Rhinitis alone and rhinitis with asthma represent two distinct phenotypes. These results reinforce the need to include asthma status in the ARIA classification and guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.12316","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T20:29:14Z","timestamp":1700857754000},"source":"Crossref","is-referenced-by-count":10,"title":["Asthma is associated with increased severity and duration of rhinitis: A study with the Allergic Rhinitis and its Impact on Asthma classes in the Constances cohort"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-8175","authenticated-orcid":false,"given":"Marine","family":"Savour\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay UVSQ Univ. Paris\u2010Sud Inserm Equipe d\u2019Epid\u00e9miologie Respiratoire Int\u00e9grative CESP  Villejuif France"},{"name":"French Environment and Energy Management Agency  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-4766","authenticated-orcid":false,"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay UVSQ Univ. Paris\u2010Sud Inserm Equipe d\u2019Epid\u00e9miologie Respiratoire Int\u00e9grative CESP  Villejuif France"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Dermatology and Allergy Comprehensive Allergy Center Berlin Institute of Health  Berlin Germany"},{"name":"Centre Hospitalier Universitaire  Montpellier France"},{"name":"MASK\u2010air  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5045-2492","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Leynaert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay UVSQ Univ. Paris\u2010Sud Inserm Equipe d\u2019Epid\u00e9miologie Respiratoire Int\u00e9grative CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2174-1126","authenticated-orcid":false,"given":"C\u00e9line","family":"Ribet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Universit\u00e9 Paris\u2010Saclay UVSQ, Inserm UMS 11 Cohortes Epid\u00e9miologiques en population  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-5880","authenticated-orcid":false,"given":"Marcel","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Universit\u00e9 Paris\u2010Saclay UVSQ, Inserm UMS 11 Cohortes Epid\u00e9miologiques en population  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-4282","authenticated-orcid":false,"given":"Marie","family":"Zins","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Universit\u00e9 Paris\u2010Saclay UVSQ, Inserm UMS 11 Cohortes Epid\u00e9miologiques en population  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-9892","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Jacquemin","sequence":"additional","affiliation":[{"name":"Univ Rennes Inserm EHESP Irset (Institut de recherche en Sant\u00e9, environnement et travail) \u2010 UMR_S 1085  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-9339","authenticated-orcid":false,"given":"Rachel","family":"Nadif","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay UVSQ Univ. 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