{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:35Z","timestamp":1790717015148,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mastocytosis manifests with multisystemic symptoms, often involving the nervous system. Numerous cognitive, neuropsychiatric and neurological alterations have been reported in multiple observational studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a qualitative systematic literature review of reported data consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We selected 24 studies in which the majority showed that a high proportion of mastocytosis patients suffer cognitive, neuropsychiatric and neurological alterations. The most common disorders and estimated ranges of frequency observed in adults were depression (68%\u201375%), anxiety, high stress or irritability (27%\u201354%), cognitive impairment (27%\u201339%, primarily affecting memory skills), and headaches (55%\u201369%). Attention challenges and learning difficulties were reported in children at a rate of 13%, while neurodevelopmental disorders occurred at rates of 8%\u201312%. Frequent white abnormalities in mastocytosis patients with concomitant psychocognitive symptoms have been reported although neuroimaging studies have been performed rarely in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further studies with more comprehensive and homogeneous evaluations and neuroimaging and histological analysis should be performed for a better understanding of these manifestations. An earlier detection and proper management of these symptoms could greatly improve the quality of life of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12319","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T15:15:15Z","timestamp":1702480515000},"source":"Crossref","is-referenced-by-count":13,"title":["Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review"],"prefix":"10.1002","volume":"13","author":[{"given":"Elena","family":"Sag\u00fces\u2010Ses\u00e9","sequence":"first","affiliation":[{"name":"Departamento de Medicina, Facultad de Medicina Universidad de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-6966","authenticated-orcid":false,"given":"Natalia","family":"Garc\u00eda\u2010Casares","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Facultad de Medicina Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Centro de Investigaciones M\u00e9dico\u2010Sanitarias (CIMES), Fundaci\u00f3n General de la Universidad de M\u00e1laga, Universidad de M\u00e1laga  M\u00e1laga Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"\u00c1lvarez\u2010Twose","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de Mastocitosis de Castilla\u2010La Mancha (CLMast) Reference Center for Mastocytosis and CIBERONC  Toledo Spain"},{"name":"Spanish Network on Mastocytosis (REMA)  Toledo and Salamanca Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM)  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26118"},{"key":"e_1_2_10_3_1","unstructured":"Mastocytosis: Statistics.Cancer.Net. 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