{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:18:02Z","timestamp":1767907082779,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute asthma exacerbation in children is often caused by respiratory infections. In this study, a coordinated national surveillance system for acute asthma hospitalizations and causative respiratory infections was established. We herein report recent trends in pediatric acute asthma hospitalizations since the COVID\u201019 pandemic in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three sentinel hospitals in Japan registered all of their hospitalized pediatric asthma patients and their causal pathogens. The changes in acute asthma hospitalization in children before and after the onset of the COVID\u201019 pandemic and whether or not COVID\u201019 caused acute asthma exacerbation were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From fiscal years 2010\u20132019, the median number of acute asthma hospitalizations per year was 3524 (2462\u20134570), but in fiscal years 2020, 2021, and 2022, the numbers were 820, 1,001, and 1,026, respectively (the fiscal year in Japan is April to March). This decrease was observed in all age groups with the exception of the 3\u2010 to 6\u2010year group. SARS\u2010CoV\u20102 was evaluated in 2094 patients from fiscal years 2020\u20132022, but the first positive case was not detected until February 2022. Since then, only 36 of them have been identified with SARS\u2010CoV\u20102, none of which required mechanical ventilation. Influenza, RS virus, and human metapneumovirus infections also decreased in FY 2020. In contrast, 24% of patients had not been receiving long\u2010term control medications before admission despite the severity of bronchial asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SARS\u2010CoV\u20102 was hardly detected in children with acute asthma hospitalization during the COVID\u201019 pandemic. This result indicated that SARS\u2010CoV\u20102 did not induce acute asthma exacerbation in children. Rather, infection control measures implemented against the pandemic may have consequently reduced other respiratory virus infections and thus acute asthma hospitalizations during this period. However, the fact that many hospitalized patients have not been receiving appropriate long\u2010term control medications is a major problem that should be addressed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12330","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T15:49:03Z","timestamp":1705592943000},"source":"Crossref","is-referenced-by-count":4,"title":["Suppressed pediatric asthma hospitalizations during the COVID\u201019 pandemic in Japan, from a national survey"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4150-3339","authenticated-orcid":false,"given":"Seigo","family":"Korematsu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center Saitama Medical University  Saitama 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