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CRS may exist with (CRSwNP) or without (CRSsNP) nasal polyps. The aim was to evaluate conditions associated with CRS in a randomized hospital cohort. We hypothesized that comorbidities and surgical procedures differ between pediatric and adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study consisted of hospital registry data of a random sample of rhinosinusitis patients (age range 0\u201389\u00a0years) with the diagnosis of J32 or J33, correspondingly, registered during outpatient visits from 2005 to 2019 (<jats:italic>n<\/jats:italic>\u00a0=\u00a01461). The covariates of interest were collected from electronic health records based on ICD\u201010 codes and keyword searches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among pediatric patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0104), the relative proportions of CRSsNP and CRSwNP were 86% and 14% respectively. The relative proportions of adult patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a01357) with CRSsNP and CRSwNP were 60% and 40%, respectively. The following comorbidities significantly differed (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) between pediatric and adult populations: allergy, chronic otitis media, and tonsillar diseases. In total, 41 % of the children and 46% of the adults underwent baseline endoscopic sinus surgery (ESS). Additional surgeries of the ear, nose and pharynx were significantly more common among children compared with adults. Risk of revision after baseline ESS was associated (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) with allergy, asthma, eosinophilia, CRSwNP, immunodeficiency or its suspicion, non\u2010steroidal anti\u2010inflammatory drug exacerbated respiratory disease, and number of any diseases \u22652.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that comorbidities differ between pediatric and adult rhinosinusitis patients, as allergy, asthma and allergy, chronic otitis media, mental health disorders, and tonsils disease were significantly more prevalent among pediatric patients. Children and adults were equally treated with ESS. Notably, children underwent additional surgery on adenoids and tonsils more frequently. The effectiveness of ESS in multimorbid adults should be assessed at an individual level.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12354","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T01:39:11Z","timestamp":1714009151000},"source":"Crossref","is-referenced-by-count":20,"title":["Comorbidities of chronic rhinosinusitis in children and adults"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5295-1572","authenticated-orcid":false,"given":"Aada","family":"Murtom\u00e4ki","sequence":"first","affiliation":[{"name":"Inflammation Center Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Department of Otorhinolaryngology University of Eastern Finland  Jouensuu, Kuopio 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