{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:25Z","timestamp":1786977505358,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The SQ tree sublingual immunotherapy (SLIT)\u2010tablet is authorised for treatment of allergic rhinoconjunctivitis with or without asthma in trees of the birch homologous group in 21 European countries. The primary objective of this study was to explore the safety in real\u2010life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective, non\u2010interventional post\u2010authorisation safety study (EUPAS31470), adverse events (AEs) and adverse drug reactions (ADRs) at first administration and follow\u2010up visits, symptoms, medication use, and pollen food syndrome were recorded by physicians in 6 European countries during the first 4\u20136\u00a0months of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ADRs with the SQ tree SLIT\u2010tablet were reported in 57.7% of 1069 total patients (median age 36.0\u00a0years, 53.7% female) during the entire observation period (severity, mild\u2010to\u2010moderate: 70.1%, severe: 4.7%, serious: 0.7%) and in 45.9% after first administration. ADRs were not increased with pollen exposure at first administration. With coadministration of the SQ tree and grass SLIT\u2010tablet AEs were reported in 73.8% of patients and in 52.8% with the SQ tree SLIT\u2010tablet\u00a0alone. Nasal and eye symptoms improved in 86.9% and 80.9% of patients and use of symptomatic medication in 76.0%. PFS with symptoms was reported in 43.0% of patients at baseline and in 4.3% at the individual last visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this non\u2010interventional safety study with the SQ tree SLIT\u2010tablet confirm the safety profile from placebo\u2010controlled clinical trials and support effectiveness in real\u2010life according to the published efficacy data. Safety was not impaired by pollen exposure at first administration or co\u2010administration with other SLIT\u2010tablets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.12373","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T23:38:12Z","timestamp":1719963492000},"source":"Crossref","is-referenced-by-count":6,"title":["Treatment with the SQ tree sublingual immunotherapy tablet is safe and well tolerated in real\u2010life"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-9639","authenticated-orcid":false,"given":"Oliver","family":"Pfaar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy University Hospital Marburg Philipps\u2010Universit\u00e4t Marburg  Marburg 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