{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:09:55Z","timestamp":1790813395647,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our population\u2010based study has previously shown that being born in winter or spring was associated with adult\u2010onset asthma. The aim was to study if season of birth (SOB) is associated with airway allergy and related diseases: NSAID exacerbated respiratory disease (N\u2010ERD), asthma, allergic rhinitis (AR), nonallergic rhinitis (NAR), chronic rhinosinusitis with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) in Finland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomly sampled retrospective registry\u2010based follow\u2010up data (<jats:italic>n<\/jats:italic>\u00a0=\u00a074,868) of patients visiting Hospital District of Helsinki and Uusimaa (HUS) in Finland was used. The birth date, sex, visit date and comorbidities were collected from electronic health record data during visits from 2005 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (SD, range) age of the sample was 34.53 (25.47, 0\u2013102) years, with 48.7 % being men. We divided the whole population in four groups based on the season they were born (SOB\u2010groups). When observing these four SOB\u2010groups, the proportion of those having asthma was 43.1%, 42.1%, 41.1%, 42.7%, in winter, spring, summer, and autumn SOB\u2010groups, respectively. The proportion of those having AR was 12.6%, 12.0%, 10.7%, 12.1%, respectively. When having summer as a reference, being born in any other time of year was significantly associated with AR and, being born in autumn or winter was associated with asthma. No significant association was observed in CRS or N\u2010ERD or NAR groups in adjusted models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study suggests that early life immunological events may have a role a role in pathogenesis of asthma and AR. As no association was observed between SOB and CRSsNP, CRSwNP, N\u2010ERD or NAR, further studies on this are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12383","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T04:13:26Z","timestamp":1721448806000},"source":"Crossref","is-referenced-by-count":5,"title":["Being born in autumn or winter is associated with asthma and allergic rhinitis in Finland"],"prefix":"10.1002","volume":"14","author":[{"given":"Riikka","family":"H\u00e4nninen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University of Eastern Finland Joensuu  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aada","family":"Murtom\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Eastern Finland Joensuu  Kuopio Finland"},{"name":"Deparment of Allergology Inflammation Center Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Hospital District of Helsinki and Uusimaa  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni","family":"Sv\u00e4rd","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Eastern Finland Joensuu  Kuopio Finland"},{"name":"Department of Otorhinolaryngology Kuopio University Hospital Wellbeing Services County of North Savo  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarno","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Eastern Finland Joensuu  Kuopio Finland"},{"name":"Department of Otorhinolaryngology Kuopio University Hospital Wellbeing Services County of North Savo  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Torkki","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Haukka","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Nuutinen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Eastern Finland Joensuu  Kuopio Finland"},{"name":"Deparment of Allergology Inflammation Center Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Hospital District of Helsinki and Uusimaa  Helsinki Finland"},{"name":"Haartman Institute University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-6686","authenticated-orcid":false,"given":"Sanna","family":"Toppila\u2010Salmi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Eastern Finland Joensuu  Kuopio Finland"},{"name":"Deparment of Allergology Inflammation Center Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Hospital District of Helsinki and Uusimaa  Helsinki Finland"},{"name":"Department of Otorhinolaryngology Kuopio University Hospital Wellbeing Services County of North Savo  Kuopio Finland"},{"name":"Haartman Institute University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocv046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398\u20109995.1993.tb00763.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15504"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12181"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.25080\/Majora-92bf1922-011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12181"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118776"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13194"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020294"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813438309038476"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.040"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15649"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12882"}],"container-title":["Clinical 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