{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:27:02Z","timestamp":1793273222597,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","award":["SGF\u20102021\u201013401"],"award-info":[{"award-number":["SGF\u20102021\u201013401"]}],"id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dupilumab has been shown to be an effective treatment in moderate\u2010to\u2010severe atopic dermatitis (AD) and severe asthma (SA). However, comparative real\u2010world analyses of adverse events (AE), particularly dupilumab\u2010associated ocular surface disease (DAOSD), are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This is the first real\u2010world study to provide insight into the prevalence of AEs associated with dupilumab in AD compared with SA. Secondary objectives were to assess the prevalence, onset and therapeutic strategies of DAOSD and evaluate dupilumab discontinuation rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from two daily practice registries including AD and SA patients receiving dupilumab treatment were analyzed. Adverse events, including DAOSD, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 322 AD and 148 SA patients were included. Headaches (23.6%), injection site reactions (10.1%), and influenza\u2010like symptoms (13.5%) were more prevalent in SA patients. Interestingly, ocular AEs were significantly more prevalent in AD patients (62.1%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), including conjunctivitis (17.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). 88% AD and 47% SA patients with ocular AEs received one or more ophthalmic treatment(s). Additionally, 20% of AD and 17.6% of SA patients discontinued dupilumab treatment due to ocular AEs, while only 65% of these AD and none of these SA patients were referred to an ophthalmologist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The higher incidence of DAOSD in AD patients compared with SA patients in this real\u2010world study highlights the importance of physician awareness, especially when prescribing dupilumab to AD patients. Conversely, the findings of this study help alleviate potential concerns about ocular AEs in patients with SA who do not have comorbid AD. Furthermore, the effective management of most ocular AEs with ophthalmic treatments suggests favorable tolerability of dupilumab in daily practice, and multidisciplinary collaboration is essential to proactively manage ocular AEs before discontinuing dupilumab.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.12386","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T03:33:13Z","timestamp":1723865593000},"source":"Crossref","is-referenced-by-count":10,"title":["Higher prevalence of dupilumab\u2010induced ocular adverse events in atopic dermatitis compared to asthma: A daily practice analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Anne R.","family":"Schl\u00f6sser","sequence":"first","affiliation":[{"name":"Department of Dermatology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1835-3195","authenticated-orcid":false,"given":"Lotte","family":"Bult","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Franciscus Gasthuis and Vlietland  Rotterdam The Netherlands"},{"name":"Department of Pulmonology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Thelen","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Franciscus Gasthuis and Vlietland  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta A. 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