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Omalizumab, a humanized anti\u2010IgE monoclonal antibody, reduces allergic reactions by binding to circulating IgE. Omalizumab has been successfully used in allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic urticaria, and was recently approved for treating IgE\u2010mediated food allergies by the US Food and Drug Administration (FDA). This GA<jats:sup>2<\/jats:sup>LEN ANACARE Consensus Statement presents our position on the use of omalizumab for treating IgE\u2010mediated food allergies, based on a systematic review and meta\u2010analysis, experience with use for other conditions, and expert consensus achieved via an eDelphi process. Following publication of the recent OUtMATCH study (stage 1) results and subsequent FDA approval, we propose that there is now sufficient evidence to recommend omalizumab as the only drug currently available that can mechanistically reduce IgE\u2010mediated food allergic reactions. 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