{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:10:47Z","timestamp":1789582247759,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on type 2 (T2)\u2010low severe asthma (SA) frequency is scarce, resulting in an undefined unmet therapeutic need in this patient population. Our objective was to assess the frequency and characterize the profile and burden of T2\u2010low SA in Greece.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PHOLLOW was a cross\u2010sectional study of adult SA patients. Based on a novel proposed classification system, patients were classified as T2\u2010low if blood eosinophil count (BEC; cells\/\u03bcL) was &lt;150, fractional exhaled nitric oxide (FeNO)\u00a0&lt;\u00a025 ppb and any allergy status or BEC &lt; 150\/FeNO &lt; 50 ppb\/no allergy or BEC &lt; 300\/FeNO &lt; 25 ppb\/no allergy. For patients receiving biologics and\/or oral corticosteroids, only those with BEC &lt; 150\/FeNO &lt; 25 ppb\/no allergy\/no response to therapy were classified as T2\u2010low. Secondary outcome measures were: Asthma Control Test (ACT\n                      <jats:sup>TM<\/jats:sup>\n                      ), Mini\u2010Asthma Quality of Life Questionnaire (Mini\u2010AQLQ), hospital anxiety and depression scale (HADS), and Work Productivity and Activity Impairment:Respiratory Symptoms (WPAI:RS) questionnaire.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 22\u2010Mar\u20102022 to 15\u2010Mar\u20102023, 602 eligible SA patients were enrolled. The frequency of T2\u2010low asthma was 20.1%. Of those, 71.1% had experienced \u22651 clinically significant exacerbations in the past year, 62.8% had ACT score &lt;20 (uncontrolled asthma), and 22.3% were biologic\u2010treated. Mini\u2010AQLQ score was &lt;6 (impairment) in 79.5% of patients, HADS\u2010total score was \u226515 (clinically significant emotional distress) in 43.8%, while median percent activity impairment and work productivity loss were 30.0 for both domains. Clinical and patient\u2010reported outcomes were worse among patients with ACT\u2010defined uncontrolled asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One\u2010fifth of SA patients present with a T2\u2010low endotype. These patients frequently have uncontrolled disease and experience impairments in their quality of life, emotions and work ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70035","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T20:34:36Z","timestamp":1738182876000},"source":"Crossref","is-referenced-by-count":12,"title":["T2\u2010low severe asthma clinical spectrum and impact: The Greek PHOLLOW cross\u2010sectional study"],"prefix":"10.1002","volume":"15","author":[{"given":"Konstantinos","family":"Porpodis","sequence":"first","affiliation":[{"name":"Pulmonary Department Aristotle University of Thessaloniki G. Papanikolaou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Zias","sequence":"additional","affiliation":[{"name":"Respiratory Department Navy Hospital of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kostikas","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department School of Medicine University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyris","family":"Tzouvelekis","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Medical School University of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Makris","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology Allergy Unit Medical School Attikon University General Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-6764","authenticated-orcid":false,"given":"George N.","family":"Konstantinou","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology 424 General Military Training Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Zervas","sequence":"additional","affiliation":[{"name":"7th Respiratory Department Athens Chest Hospital Sotiria  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelios","family":"Loukides","sequence":"additional","affiliation":[{"name":"2nd Respiratory Department Medical School Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paschalis","family":"Steiropoulos","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Medical School University General Hospital Democritus University of Thrace  Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Katsoulis","sequence":"additional","affiliation":[{"name":"Pulmonary Department 424 Army General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Palamidas","sequence":"additional","affiliation":[{"name":"Athens Medical Center\u2010Marousi Clinic  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Syrigou","sequence":"additional","affiliation":[{"name":"Allergy Department Sotiria General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gangadi","sequence":"additional","affiliation":[{"name":"10th Department of Pulmonary Medicine Athens Chest Hospital Sotiria  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital Patras  Patra Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimosthenis","family":"Papapetrou","sequence":"additional","affiliation":[{"name":"Athens Medical Group Paleo Faliro Clinic  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Psarros","sequence":"additional","affiliation":[{"name":"Allergy Department Athens Naval Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Gourgoulianis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Respiratory Medicine University Hospital of Larissa University of Thessaly  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Tzortzaki","sequence":"additional","affiliation":[{"name":"Outpatient Respiratory Clinic  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos K.","family":"Vittorakis","sequence":"additional","affiliation":[{"name":"Private Practice  Chania Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Paraskevopoulos","sequence":"additional","affiliation":[{"name":"401 General Military Hospital Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Papanikolaou","sequence":"additional","affiliation":[{"name":"Pulmonary Department Corfu General Hospital  Corfu Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Krommidas","sequence":"additional","affiliation":[{"name":"Private Practice  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Latsios","sequence":"additional","affiliation":[{"name":"Private Practice  Drama Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Tzanakis","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Medical School University General Hospital of Heraklion Laboratory of Molecular and Cellular Pneumonology University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis","family":"Markatos","sequence":"additional","affiliation":[{"name":"Outpatient Clinic for Pulmonary Diseases  Chania Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Damianaki","sequence":"additional","affiliation":[{"name":"Pulmonary and Sleep Medical Department Chania General Hospital Agios Georgios  Chania Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyrios","family":"Manikas","sequence":"additional","affiliation":[{"name":"European Interbalkan Medical Center  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Chatzipetrou","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology Allergy Unit University General Hospital Attikon National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Vourdas","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology 251 General Airforce Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Tsiouprou","sequence":"additional","affiliation":[{"name":"Pulmonary Department Aristotle University of Thessaloniki G. Papanikolaou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Papista","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Respiratory and Immunology AstraZeneca  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bartsakoulia","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Respiratory and Immunology AstraZeneca  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"Mathioudakis","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Respiratory and Immunology AstraZeneca  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Galanakis","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Respiratory and Immunology AstraZeneca  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-9656","authenticated-orcid":false,"given":"Petros","family":"Bakakos","sequence":"additional","affiliation":[{"name":"1st University Department of Respiratory Medicine National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101936"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2018.1471704"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.05.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13378"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.s327659"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0176\u20102021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3908"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010018\u20108712\u20101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00309\u20102020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9111684"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.05.027"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807\u20101291oc"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00528\u20102020"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.10.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102020\u2010215168"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress\u20102019.pa2749"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.02.059"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.s378505"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071118"},{"key":"e_1_2_9_23_1","unstructured":"JacksonDJ AljamilN RoxasC et\u00a0al.Severe 'T2 Low' Asthma Is Uncommon and Frequently Associated with Co\u2010morbidities Known to Cause Respiratory Symptoms. American Thoracic Society 2018 International Conference. A33.ASTHMA MECHANISMS.A1341."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(20)30397\u20100"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202201\u20100129oc"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00483\u20102022"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41030\u2010019\u201000109\u20101"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.105806"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1804092"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20102600(17)30344\u20102"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208\u20101414oc"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00588\u20102019"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00260\u20102020"},{"key":"e_1_2_9_34_1","unstructured":"Tezspire Approved for Self\u2010Administration in the EU in a New Pre\u2010filled Pen [Press Release 13 January 2023].https:\/\/www.astrazeneca.com\/media\u2010centre\/press\u2010releases\/2023\/tezspire\u2010approved\u2010for\u2010self\u2010administration\u2010in\u2010the\u2010eu\u2010in\u2010a\u2010new\u2010pre\u2010filled\u2010pen.html. Accessed December 11 2023."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202210\u20102005oc"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress\u20102016.pa4237"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.61873\/oufg9616"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.08.1504"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.18332\/pne\/157014"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.008"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)60617\u20106"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.053"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14112"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.01.011"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.s401445"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533474"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010020\u20101090\u20105"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u201010\u201097"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.10.010"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12054"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010022\u201002049\u20100"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.18332\/pne\/144485"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.040"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20106958\u20107\u201032"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2016.1206563"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010016\u20100374\u2010z"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp\u20102019\u2010000534"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00779\u20102015"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010053854"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020146"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1708095"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u2010859x\u20107\u20104"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010019\u20101255\u2010z"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533\u2010017\u20100014\u20101"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2017.1316394"}],"container-title":["Clinical and Translational Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clt2.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:58:26Z","timestamp":1741730306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clt2.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/clt2.70035"],"URL":"https:\/\/doi.org\/10.1002\/clt2.70035","archive":["Portico"],"relation":{},"ISSN":["2045-7022","2045-7022"],"issn-type":[{"value":"2045-7022","type":"print"},{"value":"2045-7022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"article-number":"e70035"}}