{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:34:03Z","timestamp":1758807243922,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug hypersensitivity reaction (DHR) poses significant challenges in clinical practice, with some patients experiencing more severe reactions upon re\u2010exposure. Understanding the factors contributing to escalation into more severe reactions is crucial for improving patient safety. This study aimed to investigate the clinical characteristics and risk factors associated with the progression from non\u2010severe DHR to anaphylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective study was conducted using data from a drug\u2010induced anaphylaxis registry across 10 university hospitals in Korea. Clinical data, including information on culprit drugs, DHR history, and the severity of reactions, were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 494 cases of drug\u2010induced anaphylaxis, 417 cases (84.4%) occurred without prior DHR, while 77 cases (15.6%) had a history of non\u2010severe DHR. Of these, 43 cases had a previous DHR to a drug of the same class, and 34 cases involved DHR to drugs of different classes. In the group with prior DHR to a drug of the same class, anaphylaxis occurring in daily life was significantly more common compared to those reacting to a different class of drug or those with no prior DHR (48.8% vs. 23.5% or 22.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008 and\u00a0&lt;\u00a00.001, respectively). Non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), H2 blockers, and penicillins were identified as risk factors for anaphylaxis evolving from non\u2010severe DHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enhanced vigilance is required for patients with a history of non\u2010severe DHR to NSAIDs, H2 blockers, and penicillins as re\u2010exposure may lead to the progress to anaphylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.70047","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T03:28:16Z","timestamp":1745378896000},"source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and risk factors for escalation to anaphylaxis from non\u2010severe drug hypersensitivity reaction"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-4649","authenticated-orcid":false,"given":"Hyo\u2010In","family":"Rhyou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Inje University Haeundae Paik Hospital Inje University College of Medicine  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Ryeol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine  Yongin Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Woo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul 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