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In line with the Global Airways theory, SEA and CRSwNP frequently co\u2010occur, creating a multimorbid phenotype. Separately, SEA and CRSwNP are burdensome: when concomitant, they compound each other, creating a more difficult\u2010to\u2010treat disease with increased complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Body<\/jats:title><jats:p>Current management approaches rarely control disease and are associated with substantial side\u2010effects. Several recently developed anti\u2010IL\u20105 monoclonal antibodies have shown efficacy in treating co\u2010morbid SEA with CRSwNP by targeting T2 inflammation with systemic therapies. Of these, only benralizumab directly targets the IL\u20105 receptor\u2010\u03b1, leading to rapid, sustained, near\u2010complete eosinophil depletion. Analyses in patients with co\u2010morbid SEA with CRSwNP are limited, although data from the ANDHI, XALOC\u20101, and RANS studies suggest benralizumab can effectively target inflammation underlying co\u2010morbid disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite progress toward more effective therapies, treatment approaches remain siloed, with SEA and CRSwNP often managed separately. There is a need for the development of multidisciplinary approaches for treating patients with comorbid SEA with CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.70051","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:50:43Z","timestamp":1744170643000},"source":"Crossref","is-referenced-by-count":4,"title":["Benralizumab and the integrated management of co\u2010morbid severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-5007","authenticated-orcid":false,"given":"Joaquim","family":"Mullol","sequence":"first","affiliation":[{"name":"Rhinology Unit &amp; Smell Clinic ENT Department Hospital Cl\u00ednic Barcelona Clinical and Experimental Respiratory Immunoallergy (IDIBAPS) Universitat de Barcelona CIBER de Enfermedades Respiratorias (CIBERES)  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Amato","sequence":"additional","affiliation":[{"name":"Respiratory Department Monaldi Hospital\u2010AO Dei Colli\u2010Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"de Corso","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery Fondazione Policlinico Universitario A. 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