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The aim of the present study was to investigate non\u2010genetic association factors with ACEi\u2010\/ARB\u2010induced angioedema in the European ADR database EudraVigilance and the database of the vARIANCE study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort of the vARIANCE study comprised 114 patients who suffered from ACEi\u2010 or ARB\u2010induced angioedema. In addition, 171 angioedema reports and 4650 reports on other ADRs of ACEi\/ARB were identified in the ADR database EudraVigilance with the latter serving as a reference group. Odds ratios were calculated and a logistic regression analysis was performed using angioedema versus reference reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased age, smoking, allergies and a history of previous angioedema were identified as associated factors for ACEi\u2010\/ARB\u2010induced angioedema. In most patients, the swelling affected the face, lips and tongue. In the vARIANCE study, about 70% of angioedema occurred after 1\u00a0year of treatment. For one in two patients in the vARIANCE study (84.2% with ACEi treatment) and one in three patients from the EudraVigilance reports (59.6% with ARB treatment), the angioedema resulted in hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found small to moderate associations with certain individual patient\u2010related factors in this pharmaco\u2010epidemiological study. As a future perspective, combining non\u2010genetic association factors with corresponding genetic data might provide an option to compose stronger and individual risk scores.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clt2.70058","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T01:19:39Z","timestamp":1746667179000},"source":"Crossref","is-referenced-by-count":5,"title":["Non\u2010genetic factors associated with ACE\u2010inhibitor and angiotensin receptor blocker\u2010induced angioedema"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-051X","authenticated-orcid":false,"given":"Diana","family":"Dubrall","sequence":"first","affiliation":[{"name":"Institute for Medical Biometry Informatics and Epidemiology University Hospital of Bonn  Bonn Germany"},{"name":"Research Division Federal Institute of Drugs and Medical Devices (BfArM)  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora 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