{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:25Z","timestamp":1786977505773,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary chronic rhinosinusitis (CRS) can be classified based on the sinuses involved and the dominant endotype of the mucosal inflammation. Since the introduction of type 2 targeted biologics as treatment option for CRS, assessment of the inflammatory status has gained importance in CRS patients. We here aimed to characterize CRS patients with and without elevated markers of type 2 inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CRS patients who visited the outpatient ENT clinic in one of the 10 tertiary centers in 7 European countries were invited to use the Galenus Health mobile application for the monitoring of their disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRS patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0281) were stratified according to blood eosinophil counts or BEC (&lt;\u00a0150\u00a0cells\/\u03bcL: 21.6% of patients, \u2265\u00a0150\u00a0cells\/\u03bcL: 78.4%; &lt;\u00a0250\u00a0cells\/\u03bcL: 36.3%, \u2265\u00a0250\u00a0cells\/\u03bcL: 63.7%) and serum total IgE (&lt;\u00a0100\u00a0IU\/mL: 59.9%, \u2265\u00a0100\u00a0IU\/mL: 40.1%). BEC and serum total IgE did not correlate well (Spearman\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.39). CRS patients with BEC\u00a0\u2265\u00a0150\u00a0cell\/\u03bcL or \u2265\u00a0250\u00a0cells\/\u03bcL, respectively, showed increased NPS, SNOT\u201022, VAS for total CRS symptoms, loss of smell, nasal blockage, runny nose compared to patients with BEC below 150 or 250\u00a0cells\/\u03bcL. CRS patients with increased serum total IgE (\u2265\u00a0100\u00a0IU\/mL) did not show differences in the outcome parameters compared to patients with levels below 100\u00a0IU\/mL. CRS patients with asthma (58.9%) showed increased SNOT\u201022 and VAS loss of smell compared to patients without asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A significant proportion of CRS patients exhibit a type 2 endotype, characterized by blood eosinophilia (78%), increased serum total IgE (40%) and\/or concomitant asthma (59%). Our results underline the usefulness of eosinophils as a marker of type 2 inflammation and severity but challenge the utility of serum total IgE since it does not correlate with any of the markers of severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70095","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T06:45:11Z","timestamp":1756709111000},"source":"Crossref","is-referenced-by-count":5,"title":["Characterization of Chronic Rhinosinusitis Patients Based on Markers of Type 2 Inflammation: Findings From the European CRS Outcome Registry (CHRINOSOR)"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-8935","authenticated-orcid":false,"given":"Carlo","family":"Cavaliere","sequence":"first","affiliation":[{"name":"Department of Sense Organs Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-9892","authenticated-orcid":false,"given":"Sven F.","family":"Seys","sequence":"additional","affiliation":[{"name":"Galenus Health  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"de Kinderen","sequence":"additional","affiliation":[{"name":"Galenus Health  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bettio","sequence":"additional","affiliation":[{"name":"Galenus Health  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Andrianakis","sequence":"additional","affiliation":[{"name":"Department of General ORL, Head and Neck Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Surgery Unit Otorhinolaryngology Department Hospital Clinic IDIBAPS Ciberes Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Hellings","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery UZ Leuven  Leuven Belgium"},{"name":"Allergy and Clinical Immunology Research Group Department of Microbiology, Immunology &amp; Transplantation KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Van Gerven","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery UZ Leuven  Leuven Belgium"},{"name":"Allergy and Clinical Immunology Research Group Department of Microbiology, Immunology &amp; Transplantation KU Leuven  Leuven Belgium"},{"name":"Department of Neurosciences Experimental Otorhinolaryngology Rhinology Research KU Leuven  Leuven 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Vienna General Hospital (AKH) Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u2010Valentin","family":"Tomazic","sequence":"additional","affiliation":[{"name":"Department of General ORL, Head and Neck Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Diamant","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Research Group Department of Microbiology, Immunology &amp; Transplantation KU Leuven  Leuven Belgium"},{"name":"Department of Respiratory Medicine First Faculty of Medicine Charles University and Thomayer Hospital  Prague Czech Republic"},{"name":"Department of Clinical Pharmacology and Pharmacology 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