{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:03:55Z","timestamp":1790240635225,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mobile health technologies may improve the management of chronic diseases, such as chronic spontaneous urticaria. However, effectiveness of mHealth tools largely depends on patient adherence, which can be influenced by various demographic, clinical, behavioural, psychosocial factors, and apps characteristics (appealing and simplicity of use). Understanding these adherence patterns is crucial for optimizing mHealth interventions. In this study, we aimed to assess adherence patterns associated to the use of CRUSE, a mHealth app designed for patients with CSU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed users of the CRUSE app with self\u2010reported CSU or suggested by a physician. For each user, we evaluated the number of days they completed the CRUSE daily monitoring questionnaire (app adherence) within the first 3\u00a0months after installation. We constructed univariable and multivariable ordered beta regression models to identify predictors of 3\u2010month adherence to the app.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed data from 2085 patients (66,114\u00a0days). Median adherence to the CRUSE app was of 22\u00a0days (24.4% of 90\u00a0days). In multivariable regression models, the variables more strongly associated with increased adherence to CRUSE included age (average increase\u00a0=\u00a00.16 percent points [pp] per additional year; 95% credible interval [CrI]\u00a0=\u00a00.08; 0.23 pp), male sex (average difference\u00a0=\u00a04.24 pp; 95% CrI\u00a0=\u00a01.77; 6.39 pp), being from a European country (average difference\u00a0=\u00a02.66 pp; 95% CrI\u00a0=\u00a00.59; 5.19 pp), and using monoclonal antibodies (average difference\u00a0=\u00a04.60 pp; 95% CrI\u00a0=\u00a02.26; 6.65 pp).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that age, male sex, residence in Europe, and the use of monoclonal antibodies are significant factors associated with increased adherence to the CRUSE app. These insights may help identify patient subgroups who would benefit most from mHealth support in managing CSU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70110","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T20:06:07Z","timestamp":1763237167000},"source":"Crossref","is-referenced-by-count":3,"title":["Key Predictors of Adherence to a Mobile Health App for Managing Chronic Spontaneous Urticaria"],"prefix":"10.1002","volume":"15","author":[{"given":"Hugo","family":"Viegas","sequence":"first","affiliation":[{"name":"MEDCIDS\u2014Department of Community Medicine Information and Health Decision Sciences Faculty of Medicine University of Porto  Porto Portugal"},{"name":"CINTESIS@RISE Centre for Health Technology and Services Research Health Research Network Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Sousa\u2010Pinto","sequence":"additional","affiliation":[{"name":"MEDCIDS\u2014Department of Community Medicine Information and Health Decision Sciences Faculty of Medicine University of Porto  Porto Portugal"},{"name":"CINTESIS@RISE Centre for Health Technology and Services Research Health Research Network Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1834-3055","authenticated-orcid":false,"given":"Rafael Jos\u00e9","family":"Vieira","sequence":"additional","affiliation":[{"name":"MEDCIDS\u2014Department of Community Medicine Information and Health Decision Sciences Faculty of Medicine University of Porto  Porto Portugal"},{"name":"CINTESIS@RISE Centre for Health Technology and Services Research Health Research Network Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiste","family":"Ramanauskaite","sequence":"additional","affiliation":[{"name":"Institute of Allergology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Witte\u2010H\u00e4ndel","sequence":"additional","affiliation":[{"name":"Institute of Allergology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana","family":"Gimenez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Urticaria Center of Reference, and Excellence (UCARE) Hospital del Mar IMIM Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Guillet","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Alberto","family":"Salvador Parisi","sequence":"additional","affiliation":[{"name":"Adult and Pediatric Allergy Sections of the Italian Hospital of Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Katelaris","sequence":"additional","affiliation":[{"name":"Department of Medicine Campbelltown Hospital and Western Sydney University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Fomina","sequence":"additional","affiliation":[{"name":"Moscow City Research and Practical Center of Allergology and Immunology Clinical 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