{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:57:06Z","timestamp":1791633426122,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460220"],"award-info":[{"award-number":["82460220"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1411700"],"award-info":[{"award-number":["21ZR1411700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["24SF1904700"],"award-info":[{"award-number":["24SF1904700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impairs the quality of life, and disease control is now considered the primary treatment goal. Although patient\u2010reported outcome measures (PROMs) such as the 22\u2010item Sinonasal Outcome Test (SNOT\u201022) and CRS\u2010PRO are widely used, their utility in predicting long\u2010term postoperative disease control remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective follow\u2010up study aimed to evaluate postoperative recovery and identify the predictors of suboptimal disease control in patients with CRSwNP by integrating preoperative PROMs with objective clinical features. A total of 102 patients with CRSwNP undergoing functional endoscopic sinus surgery (FESS) were enrolled, of whom 89 completed at least 12\u00a0months of follow\u2010up. Preoperative and postoperative PROMs were compared across disease control groups classified based on the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 criteria. Least absolute shrinkage and selection operator regression was applied to select objective clinical predictors, which were then combined with either CRS\u2010PRO or SNOT\u201022 item scores to develop and compare the nine machine learning models. Model performance was assessed using area under the curve (AUC), decision curve analysis, sensitivity, specificity, and other metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eosinophil and neutrophil counts were identified as key objective predictors of suboptimal disease control after FESS. Among all models, logistic regression incorporating CRS\u2010PRO scores and selected clinical features achieved the best performance, yielding an AUC of 0.866, accuracy of 83.3%, sensitivity of 72.7%, specificity of 89.5%, and F1\u2010score of 76.2%. This model demonstrated a strong discriminatory ability and potential utility in individualized clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Integrating preoperative CRS\u2010PRO item scores with selected objective clinical parameters enables the accurate prediction of suboptimal disease control in patients with CRSwNP following FESS. This approach supports personalized risk stratification and postoperative management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70119","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:59:47Z","timestamp":1762282787000},"source":"Crossref","is-referenced-by-count":1,"title":["Patient\u2010Reported Outcome Measures as Predictive Tools for Disease Control in Chronic Rhinosinusitis With Nasal Polyps: A Prospective Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Chen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"High Altitude Rhinology Research Center of Eye &amp; ENT Hospital of Fudan University and People's Hospital of Shigatse City  Shigatse China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; ENT Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; ENT Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; ENT Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; ENT Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; ENT Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Institute Eye &amp; 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