{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:58:20Z","timestamp":1785423500741,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000962"],"award-info":[{"award-number":["82000962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171110"],"award-info":[{"award-number":["82171110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471137"],"award-info":[{"award-number":["82471137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["Z\u20102018\u201031\u20102108"],"award-info":[{"award-number":["Z\u20102018\u201031\u20102108"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eucalyptol, limonene, and pinene enteric capsules (ELP) are typical mucoactive drugs used in chronic rhinosinusitis with nasal polyps (CRSwNP). However, reliable evidence regarding its efficacy in this population remains limited. This study aimed to evaluate the clinical efficacy and safety of ELP, particularly on nasal ciliary function and inflammatory biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, randomized, controlled, multicenter clinical study enrolled CRSwNP patients who underwent endoscopic sinus surgery (ESS). Participants were randomly assigned at a 1:2 ratio to the intranasal corticosteroid (INCS) group or the ELP\u00a0+\u00a0INCS group. Clinical outcomes were assessed over 12\u00a0weeks using sinus computed tomography, nasal endoscopy, saccharin tests (STs) and the 22\u2010item sinonasal outcome tests (SNOT\u201022). Local inflammation in nasal secretions were quantified via a Luminex assay, and adverse effects (AEs) was monitored throughout the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 174 CRSwNP patients were included in the final analysis. Compared to the INCS group, the ELP\u00a0+\u00a0INCS group demonstrated significantly greater improvements in Lund\u2010Mackay score (LMS) and Lund\u2010Kennedy score (LKS) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029 and 0.025, respectively). A higher proportion of patients in the ELP\u00a0+\u00a0INCS group also showed improvement in the runny nose score (weeks 8 and 12), cough score (week 4), and frustration score (week 8). Furthermore, STT was significantly shorter in the ELP\u00a0+\u00a0INCS group at week 4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015). Subgroup analysis revealed that the ELP\u00a0+\u00a0INCS group had significantly lower concentrations of granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF), interleukin (IL)\u20104, granulocyte colony\u2010stimulating factor (G\u2010CSF) and thrombopoietin (Tpo) compared to the INCS group. No significant difference was observed in the incidence of AEs between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of ELP and INCS represents an effective and well\u2010tolerated treatment strategy for patients with CRSwNP following endoscopic sinus surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The trial was registered with the Chinese Clinical Trial Registry (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/\">www.chictr.org.cn<\/jats:ext-link>\n                      ; registration number ChiCTR2200055224)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70123","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:36:46Z","timestamp":1764661006000},"source":"Crossref","is-referenced-by-count":1,"title":["A Multicenter, Randomized, Controlled Clinical Trial on the Efficacy and Safety of Eucalyptol, Limonene, and Pinene Enteric Capsules in the Treatment of Chronic Rhinosinusitis With Nasal Polyps Postoperatively"],"prefix":"10.1002","volume":"15","author":[{"given":"Yutong","family":"Sima","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"},{"name":"Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of New Medicine and Diagnostic Technology Research for Nasal Disease Beijing Institute of Otolaryngology  Beijing 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Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Skull Base Surgery Center Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Skull Base Surgery Center Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College  Beijing 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Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University  Beijing 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