{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:04Z","timestamp":1792124884920,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The SYNAPSE phase 3 study demonstrated that mepolizumab significantly improves nasal polyp score (NPS), quality of life and symptom severity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to evaluate mepolizumab effectiveness in a real\u2010world cohort from 12 tertiary centers in 6 European countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted in 110 CRSwNP patients (comorbid asthma: 86.4%). CRS\u2010related outcomes were analyzed at baseline, 24 and 52\u00a0weeks of mepolizumab. Treatment response was evaluated based on EUFOREA 2021 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant improvements in NPS, Sinonasal Outcome Test\u201022 (SNOT\u201022), and visual analog scale (VAS) symptom scores were observed at 24 and 52\u00a0weeks compared to baseline. Further improvement between weeks 24 and 52 was observed for NPS and SNOT\u201022. Asthma Control Test (ACT) also improved significantly by week 24 (ACT score \u2265\u00a020: 64.5%). At least one response criterion (change in SNOT\u201022\u00a0\u2265\u00a08.9, NPS \u2265\u00a01, VAS total sinus symptoms \u2265\u00a020, VAS nasal blockage \u2265\u00a020, VAS loss of smell \u2265\u00a020) was met by 85.6% and 78.7% of patients at 24 and 52\u00a0weeks, respectively. A more stringent composite response (SNOT\u201022\u00a0&lt;\u00a030, NPS &lt;\u00a04, VAS total sinus symptoms &lt;\u00a050, and VAS nasal blockage &lt;\u00a050) was achieved in 18.3% and 44.6% of patients at 24 and 52\u00a0weeks, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mepolizumab demonstrated clinically meaningful benefits in a real\u2010world CRSwNP population, with nearly half of patients achieving a beneficial composite treatment response by week 52. Notably, progressive improvements between weeks 24 and 52 underscore the value of prolonged therapy and the importance of evaluating treatment response at one year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70153","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:34:36Z","timestamp":1769913276000},"source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Effectiveness of Mepolizumab in Patients With Chronic Rhinosinusitis With Nasal Polyps: Findings From the European CRS Outcome Registry (CHRINOSOR)"],"prefix":"10.1002","volume":"16","author":[{"given":"Isam","family":"Alobid","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Department Rhinology Unit &amp; Smell Clinic and Skull Base Surgery Unit Hospital Clinic Barcelona Universitat de Barcelona IDIBAPS CIBERES  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-9892","authenticated-orcid":false,"given":"Sven F.","family":"Seys","sequence":"additional","affiliation":[{"name":"Galenus Health (part of Cascador Health Group)  Tielrode Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"de Kinderen","sequence":"additional","affiliation":[{"name":"Galenus Health (part of Cascador Health Group)  Tielrode Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Hox","sequence":"additional","affiliation":[{"name":"Service d'Otorhinolaryngologie Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-8935","authenticated-orcid":false,"given":"Carlo","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Health and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Andrianakis","sequence":"additional","affiliation":[{"name":"Department of General ORL, Head and Neck Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Vienna General Hospital (AKH) Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wagenmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Universit\u00e4tsklinikum D\u00fcsseldorf (UKD)  Dusseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bruch","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Ordensklinikum Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Izquierdo\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Allergology Department Hospital Universitario de Terrassa  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gonzalez\u2010Compta","sequence":"additional","affiliation":[{"name":"Rhinology Unit, Otorhinolaryngology Department, Hospital Universitari de Bellvitge Universitat de Barcelona, IDIBELL  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Pardo","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department Hospital Universitari Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Van Gerven","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery UZ Leuven  Leuven Belgium"},{"name":"Department of Microbiology, Immunology &amp; 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