{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:50:55Z","timestamp":1788155455368,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016730","name":"Torii Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Japanese cedar (JC) pollen sublingual immunotherapy (SLIT)\u2010tablets (5000 Japanese allergy units [JAU]) are licensed for the treatment of JC\u2010pollinosis with no age restriction on the basis of the results of a 5\u2010year clinical trial. However, there have been no large\u2010scale surveys of 5000 JAU in an actual clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter observational prospective study. We assessed the safety and effectiveness of the long\u2010term use of 5000 JAU in patients with JC\u2010pollinosis, with an observation period of two seasons of JC pollen dispersal, at clinical sites in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our safety analysis included 516 patients and the effectiveness analysis included 469 patients. Adverse drug reactions (ADRs) occurred in 68 patients (13.18%) and mainly comprised administration site\u2010related events that occurred during the early phase of administration. Treatment discontinuation due to ADRs occurred in 18 patients (3.49%). No deaths, anaphylactic shock, or serious ADRs occurred. Regarding effectiveness, the severity of JC\u2010pollinosis was rated as \u201calmost asymptomatic +\u00a0mild\u201d in 82.19% of patients in Season 1 and 92.58% in Season 2. Quality of life was rated as \u201cscore 0 (Fine)\u00a0+\u00a01\u201d in 75.83% of patients in Season 1 and 86.09% in Season 2. Overall improvement was rated as \u201cimproved\u00a0+\u00a0slightly improved\u201d in 95.68% of patients in Season 1 and 96.38% in Season 2 following the initiation of JC pollen SLIT\u2010tablets. Nasal and ocular symptom scores also decreased with increasing treatment duration. Treatment continuation rates were 89.53% in Season 1 and 78.29% in Season 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The JC pollen SLIT\u2010tablets appear to be safe and effective in an actual clinical setting during two seasons. No new safety or effectiveness issues were identified, and no additional safety or effectiveness precautions were required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70157","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:45:22Z","timestamp":1771040722000},"source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010Life Safety of Japanese Cedar Pollen Sublingual Immunotherapy Tablets: A Post\u2010Marketing Survey"],"prefix":"10.1002","volume":"16","author":[{"given":"Minoru","family":"Gotoh","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3476-6583","authenticated-orcid":false,"given":"Yuriko","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Medical Information Pharmacovigilance &amp; Quality Assurance Group Torii Pharmaceutical Co. 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