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Among 3546 participants with data on physician\u2010diagnosed asthma and onset age, 46.4% were defined as adult\u2010onset [864 (24.4%) had early adult\u2010onset asthma (18\u201339\u00a0years) and 782 (22.1%) had late adult\u2010onset asthma (\u2265\u00a040\u00a0years)], which, compared to childhood\u2010onset asthma, presented with more complex, multi\u2010symptom profiles, including productive cough, sputum production, but less wheezing. Allergy\u2010related comorbidities were more common in childhood\u2010diagnosed asthma, while chronic obstructive pulmonary disease (COPD), diabetes mellitus, hypertension, obesity, and chronic sinusitis were more common in adult\u2010onset asthma. Adult\u2010onset asthma also had a higher disease burden, with more frequent medication use and exacerbations. Adult\u2010onset asthma has an underlying complexity, contributing to a vicious cycle of worsening symptoms, increased medication use, and more comorbidities.<\/jats:p>","DOI":"10.1002\/clt2.70160","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:15:58Z","timestamp":1771103758000},"source":"Crossref","is-referenced-by-count":1,"title":["Adult\u2010Onset Compared to Childhood\u2010Onset Asthma: Multifaceted Symptoms, Comorbidity, and Healthcare Burden"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-2912","authenticated-orcid":false,"given":"Reshed","family":"Abohalaka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-773X","authenticated-orcid":false,"given":"Saliha Selin","family":"Ozuygur Ermis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-8067","authenticated-orcid":false,"given":"Helena","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"R\u00e5dinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bright I.","family":"Nwaru","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kankaanranta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Department of Respiratory Medicine Sein\u00e4joki Central Hospital  Sein\u00e4joki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.70015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/514868"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.06.017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.10.024"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100675"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010027808"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398\u20109995.2002.23504.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(47)90204\u20100"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00172846"}],"container-title":["Clinical and Translational 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