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In Europe, BLAL prevalences are lower (0.6%\u20135%) and the association with clinical outcomes insufficiently explored. Therefore, we assessed the association between BLAL and penicillin allergy label (PenAL) and clinical outcomes and antibiotic use in hospitalized patients in Belgium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective population\u2010based cohort study of all patients admitted to the University Hospitals Leuven between 2010 and 2018 for pneumonia, pyelonephritis (therapeutic indications), or appendectomy, coronary artery bypass grafting, total knee or hip replacement (prophylactic indications) or heart, kidney, liver, or lung transplantation (mixed indications). Multivariable regression analysis was performed, using BLAL or PenAL as independent variable, and age, gender, Charlson Comorbidity Index, and diagnosis as a priori hypothesized confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 21,999 patients accounting for 23,842 admissions. A BLAL was recorded in 1394 (6.3%) patients, with 1113 (5.1%) having an unspecified PenAL. An increased use of next\u2010line antibiotics was observed among patients with BLAL or PenAL. However, BLAL or PenAL were not associated with altered in\u2010hospital or 3\u2010month post\u2010hospitalization mortality, LOS or ICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite altered antibiotic use, we observed no association of BLAL or PenAL with clinical outcome parameters, highlighting regional differences and limiting transferability of non\u2010EU findings to guide EU delabeling protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70166","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:48:26Z","timestamp":1774669706000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcome Associated With Beta\u2010Lactam Allergy Labels in Hospitalized Patients in 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Hospital of Tours (CHRU de Tours)  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Mirela","family":"Chiriac","sequence":"additional","affiliation":[{"name":"Division of Allergy, Department of Pulmonology H\u00f4pital Arnaud de Villeneuve, University Hospital of Montpellier  Montpellier France"},{"name":"IDESP, UMR UA11, University of Montpellier\u2014INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy E.","family":"Peetermans","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical Infectious and Inflammatory Disorders KU Leuven  Leuven Belgium"},{"name":"Department of General Internal Medicine, Infectiology Unit University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul De","family":"Munter","sequence":"additional","affiliation":[{"name":"Department of Microbiology, 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