{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:52:06Z","timestamp":1781614326013,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hereditary Angioedema due to C1\u2010inhibitor deficiency (HAE\u2010C1INH) is a rare disease that affects individuals of all ages, however, older adults have never been characterized in terms of disease severity, comorbidities, and treatments. The aim was to identify the clinical characteristics of and therapeutic approaches in HAE\u2010C1INH patients aged 65 and older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the ITACA (Italian network for Hereditary and Acquired Angioedema) Registry were prospectively collected for 10\u2010month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 647 HAE\u2010C1INH, patients including 343 females (53%), were collected: 114 patients (17.6%) were aged 65 and older (68 females; 58.6%). Group mean age was 74.3\u00a0\u00b1\u00a07.5\u00a0years, mean age at first\u2010symptom\u2010onset was 19\u00a0\u00b1\u00a015\u00a0years, and mean age at diagnosis was 45.6\u00a0\u00b1\u00a014.3\u00a0years. Common comorbidities were: hypertension (59.6%), dyslipidaemia (28.9%), coronary artery disease (14.0%), diabetes (14.0%), endocrinopathies (14.0%), neoplasia (12.3%) and B\/C hepatitis (11.4%). Half of the older patients (49%) experienced at least one attack during the study period, and 8 patients (7%) had an attack frequency of\u00a0&gt;\u00a00.5 attacks\/month. Long\u2010term prophylaxis (LTP) was the treatment of choice in 45 patients (39.5%) and represented 15.9% of overall LTP prescriptions: 60% were treated with lanadelumab, 22.2% with attenuated androgens, 13.3% with berotralstat, and 4.5% with sub\u2010cutaneous C1INH concentrate. Gender differences were not detected in any of the variables analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older patients with HAE\u2010C1INH constitute a relevant subgroup, characterized by persistent disease activity and comorbidities. The availability of new therapies and guideline recommendations are driving an increase in LTP use, although shifting from older non\u2010specific treatments, especially androgens, is still incomplete.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70171","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:45:41Z","timestamp":1779385541000},"source":"Crossref","is-referenced-by-count":0,"title":["The Neglected Older Adults in Hereditary Angioedema: Insights From the ITACA Registry"],"prefix":"10.1002","volume":"16","author":[{"given":"Francesca","family":"Perego","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Istituti Clinici Scientifici Maugeri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzurra Cesoni","family":"Marcelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Istituti Clinici Scientifici Maugeri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Senter","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University Hospital of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza Chiara","family":"Zingale","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Istituti Clinici Scientifici Maugeri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-1091","authenticated-orcid":false,"given":"Antonio","family":"Gidaro","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. 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Sacco Hospital, ASST\u2010fbf\u2010sacco  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arcoleo","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Immunology Azienda Ospedaliera Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Andrea","family":"Accardo","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Immunology Azienda Ospedaliera Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Lo Pizzo","sequence":"additional","affiliation":[{"name":"Clinical Pathology and Immunology Azienda Ospedaliera Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zanichelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health University of Milan  Milan Italy"},{"name":"Operative Unit of Medicine, Angioedema Center IRCCS Policlinico San Donato  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Giardino","sequence":"additional","affiliation":[{"name":"A.O.U. 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