{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:45:41Z","timestamp":1782474341427,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR 156"],"award-info":[{"award-number":["SFB\/TRR 156"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG SCHA 1693_2\u20101"],"award-info":[{"award-number":["DFG SCHA 1693_2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Unverified antibiotic allergy labels lead to suboptimal antimicrobial prescribing and increased antibiotic resistance. Cephalosporins are among the most frequently administered antibiotics and cephalosporin allergy labels increasingly limit optimal therapy. Clinical decision rules that enable delabeling of low\u2010risk patients by non\u2010allergists are emerging as important tools. The PEN\u2010FAST score is a validated rule for identifying low\u2010risk penicillin allergy labels suitable for direct drug challenge. CEPH\u2010FAST is a recently proposed adaptation for cephalosporin allergy. We evaluated the diagnostic performance of PEN\u2010FAST and CEPH\u2010FAST for cephalosporin allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective cohort study, 100 adults with reported cephalosporin allergy labels underwent allergy assessment including skin testing and drug provocation testing at a tertiary allergy clinic in Heidelberg, Germany. Logistic regression was used to identify predictors of confirmed allergy. Diagnostic performance of PEN\u2010FAST and CEPH\u2010FAST scores was assessed using sensitivity, specificity, predictive values, and area under the receiver operating curve (AU\u2010ROC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cephalosporin allergy was confirmed in 48 of 100 patients. PEN\u2010FAST categorized 20 patients at low risk, of whom one had a positive skin test (NPV 95.0%, sensitivity 97.9%, AU\u2010ROC 0.769). CEPH\u2010FAST classified 42 patients low\u2010risk, but 12 had confirmed allergies (NPV 71.4%, sensitivity 75.0%, AU\u2010ROC 0.667). Higher PEN\u2010FAST and CEPH\u2010FAST scores were significantly associated with confirmed allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PEN\u2010FAST demonstrated high sensitivity and negative predictive value for identifying low\u2010risk cephalosporin allergy and may support safe delabeling strategies. In contrast, CEPH\u2010FAST showed reduced diagnostic performance in this cohort, highlighting the need for further validation before routine clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70178","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:43:48Z","timestamp":1779932628000},"source":"Crossref","is-referenced-by-count":0,"title":["Performance of PEN\u2010FAST and CEPH\u2010FAST for Cephalosporin Allergy Delabeling"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8019-7144","authenticated-orcid":false,"given":"Deniz","family":"G\u00f6cebe","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Heidelberg  Heidelberg Germany"},{"name":"Department of Cardiology, Angiology and Pneumology University Hospital Heidelberg  Heidelberg 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