{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:45:42Z","timestamp":1782474342555,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201300247"],"award-info":[{"award-number":["2019\u201300247"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010234","name":"Astma- och Allergif\u00f6rbundet","doi-asserted-by":"publisher","award":["F2021\u20100041"],"award-info":[{"award-number":["F2021\u20100041"]}],"id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As a surrogate for eosinophilic activation, eosinophil\u2010derived neurotoxin (EDN) is a potential clinical biomarker. However, EDN levels and discriminatory ability in different asthma phenotypes are unknown. We quantified serum and nasal lavage fluid (NLF) EDN levels and assessed the potential to differentiate clinically defined asthma phenotypes in an adult\u2010representative sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 1499 serum and 386 NLF samples from individuals with current asthma obtained from the West Sweden Asthma Study were analyzed for EDN. Eosinophilic asthma was defined as blood eosinophil count of \u2265\u00a0300 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      , T2\u2010high asthma was defined as blood eosinophil count of \u2265\u00a0300 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      or fractional exhaled nitric oxide (FeNO) levels of \u2265\u00a025 ppb. Other asthma phenotypes were defined based on presence of atopy, chronic rhinosinusitis (CRS), nasal polyposis, and obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects with eosinophilic asthma had higher serum and NLF EDN levels than those with non\u2010eosinophilic asthma. In ROC analyses, serum EDN provided excellent discrimination between eosinophilic and non\u2010eosinophilic asthma (area under curve [AUC]\u00a0=\u00a00.84, 95% CI\u00a0=\u00a00.82\u20130.86); the corresponding AUC for NLF EDN was 0.67 (95% CI\u00a0=\u00a00.62\u20130.73). Serum and NLF EDN were higher in atopic asthma, T2\u2010high asthma, and asthma with nasal polyposis compared to their counterparts, but not in asthma with CRS. The highest absolute values of serum and NLF EDN were observed in the high eosinophil\u00a0+\u00a0FeNO group, followed by the high\u2010eosinophil\u2010only and high\u2010FeNO\u2010only groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both serum and NLF EDN were higher in those with eosinophilic compared to non\u2010eosinophilic asthma. However, only serum EDN appears to distinguish eosinophilic asthma in ROC analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70183","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:45:47Z","timestamp":1782272747000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum and Nasal Lavage Fluid Eosinophil\u2010Derived Neurotoxin Levels in Clinically Defined Asthma Phenotypes"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-773X","authenticated-orcid":false,"given":"Saliha Selin","family":"\u00d6zuygur Ermis","sequence":"first","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6696-7570","authenticated-orcid":false,"given":"Carina","family":"Malmh\u00e4ll","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-2304","authenticated-orcid":false,"given":"Magnus P.","family":"Borres","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"},{"name":"Thermo Fisher Scientific  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6611-5036","authenticated-orcid":false,"given":"Robert","family":"Mov\u00e9rare","sequence":"additional","affiliation":[{"name":"Thermo Fisher Scientific  Uppsala Sweden"},{"name":"Department of Medical Sciences: Respiratory, Allergy and Sleep Research Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0220-5961","authenticated-orcid":false,"given":"Daniil","family":"Lisik","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Public Health and Clinical Medicine, Section of Sustainable Health The OLIN Unit Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-2912","authenticated-orcid":false,"given":"Reshed","family":"Abohalaka","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Institute of Medicine Sahlgrenska Academy University of Gothenburg  Gothenburg 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