{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:17:16Z","timestamp":1787815036926,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In a large randomized controlled trial (NCT02443805) in moderate\u2010to\u2010severe house dust mite (HDM) allergic rhinitis (AR) patients with\/without controlled asthma, the 300IR HDM sublingual immunotherapy (SLIT) tablet confirmed its efficacy in reducing symptoms and rescue medication (RM) use. This post hoc analysis aimed at assessing the potential steroid sparing effect of this tablet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants receiving 300IR HDM SLIT\u2010tablet or placebo for \u223c12\u00a0months could use antihistamines (AH1), corticosteroids (CS \u2013 intranasal (INCS), or oral (OCS)) in a stepwise manner for subjective intolerable nasal\/ocular symptoms. The proportions of patients and days with RM intake (overall and by drug class) were assessed over time and compared between groups (Chi\u2010squared or Wilcoxon rank\u2010sum tests). An odds that is, ratio of probability of using CS\/probability of not using CS was calculated. Mean weekly CS doses were analyzed by ANCOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1262 evaluable patients, \u223c60% used at least one CS at baseline: 300IR\u00a0=\u00a0373 and placebo\u00a0=\u00a0396. During treatment, the proportions of patients using RM, oral AH1, and CS and of days with RM use decreased in both groups, systematically in favor of 300IR (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 at end\u2010of\u2010treatment). Odds results indicated SLIT\u2010patients were more likely not to use CS, whereas placebo\u2010patients were more likely to use CS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 at end\u2010of\u2010treatment). After 12\u00a0months, 54% SLIT\u2010patients were able to discontinue CS completely versus 42% placebo\u2010patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0007). Those who were still using CS were taking fewer and lower doses than placebo\u2010patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In moderate to severe HDM\u2010AR patients, the 300IR HDM SLIT\u2010tablet showed a steroid sparing effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70185","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:48:49Z","timestamp":1786474129000},"source":"Crossref","is-referenced-by-count":0,"title":["Steroid Sparing Effect of 300IR House Dust Mite Sublingual Immunotherapy Tablet in Mite Allergic Rhinitis"],"prefix":"10.1002","volume":"16","author":[{"given":"Oliver","family":"Pfaar","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps\u2010Universit\u00e4t Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Demoly","sequence":"additional","affiliation":[{"name":"University Hospital of Montpellier and IDESP UMR 1318 University of Montpellier \u2013 Inserm \u2013 Inria Premedical  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-8468","authenticated-orcid":false,"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[{"name":"Center for Rhinology and Allergology  Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-2754","authenticated-orcid":false,"given":"Carmen","family":"Vidal","sequence":"additional","affiliation":[{"name":"Allergy Department Complejo Hospitalario Universitario de Santiago Faculty of Medicine University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1245","authenticated-orcid":false,"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Dermatology and Allergology Charit\u00e9\u2010Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolf","family":"Brehler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergology, Occupational Dermatology University Hospital M\u00fcnster  M\u00fcnster 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