{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:59:57Z","timestamp":1785265197116,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/39\/B\/NZ5\/02296"],"award-info":[{"award-number":["2020\/39\/B\/NZ5\/02296"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Up to 50% of patients with nonsteroidal anti\u2010inflammatory drug\u2010exacerbated respiratory disease (N\u2010ERD) exhibit a noneosinophilic airway inflammatory phenotype, with paucigranulocytic asthma being the most prevalent. The aim was to identify clusters within N\u2010ERD and aspirin\u2010tolerant asthma (ATA) controls with a paucigranulocytic asthma phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two separate hierarchical cluster analyses were performed using 23 variables in 36 N\u2010ERD patients and 19 ATA controls. Variables included demographic, clinical, treatment\u2010related, and hematologic parameters; sputum cytology; sinus computed tomography findings; and eicosanoid levels in induced sputum supernatant (ISS) and urine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two clusters were identified in each group: 1\n                      <jats:sub>N\u2010ERD<\/jats:sub>\n                      , 2\n                      <jats:sub>N\u2010ERD<\/jats:sub>\n                      , 1\n                      <jats:sub>ATA<\/jats:sub>\n                      , and 2\n                      <jats:sub>ATA<\/jats:sub>\n                      . Cluster 1\n                      <jats:sub>N\u2010ERD<\/jats:sub>\n                      patients had less severe asthma and required lower doses of inhaled corticosteroids (ICS) but showed higher blood eosinophil counts, Lund\u2010Mackay (LM) scores, and ISS leukotriene E\n                      <jats:sub>4<\/jats:sub>\n                      (LTE\n                      <jats:sub>4<\/jats:sub>\n                      ) levels than those in cluster 2\n                      <jats:sub>N\u2010ERD<\/jats:sub>\n                      . Cut\u2010off values defining a T2\u2010high paucigranulocytic asthma profile in N\u2010ERD included LM score \u2265\u00a018, blood eosinophils \u2265\u00a0300\u00a0cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      , and ISS LTE\n                      <jats:sub>4<\/jats:sub>\n                      \u2265\u00a030\u00a0pg\/mL, with the LM score demonstrating the highest AUC at 0.8. Among ATA controls, cluster 1\n                      <jats:sub>ATA<\/jats:sub>\n                      had more severe asthma, higher ICS doses, more severe sinonasal disease, and increased ISS leukotriene D\n                      <jats:sub>4<\/jats:sub>\n                      and LTE\n                      <jats:sub>4<\/jats:sub>\n                      levels compared with cluster 2\n                      <jats:sub>ATA<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Two clusters were identified among N\u2010ERD patients with a paucigranulocytic asthma phenotype. Cluster 1\n                      <jats:sub>N\u2010ERD<\/jats:sub>\n                      was characterized by milder asthma, more severe sinonasal disease, elevated blood eosinophil counts, and elevated ISS LTE\n                      <jats:sub>4<\/jats:sub>\n                      . This T2\u2010high\u2010like cluster may represent a subgroup requiring further evaluation for anti\u2010T2 biologic therapy targeting chronic rhinosinusitis with nasal polyps, although further validation is required.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70186","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T04:13:08Z","timestamp":1784520788000},"source":"Crossref","is-referenced-by-count":0,"title":["Paucigranulocytic Asthma in Aspirin\u2010Hypersensitive Patients: Pleiotropic Regulation of Type 2 Biomarkers"],"prefix":"10.1002","volume":"16","author":[{"given":"Rados\u0142aw","family":"Kacorzyk","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine Jagiellonian University Medical College  Krakow Poland"},{"name":"Doctoral School of Medical and Health Sciences Jagiellonian University Medical College  Krakow 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