{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:59:52Z","timestamp":1785265192932,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parenteral depot corticosteroids (PDCs) continue to be prescribed for allergic and respiratory diseases, despite clear guideline recommendations against their use. This clinical practice raises significant safety concerns. We analyzed current PDC use in Germany and characterized prescribing patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of anonymized, longitudinal prescription data (IQVIA LRx) and evaluation of anonymized electronic medical record (EMR) data (IQVIA Disease Analyzer) from October 2023 to September 2024. Data were stratified by diagnosis, prescription frequency, prescriber specialty, region, age group and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis of prescription data revealed that 9984 asthma and 5279 chronic obstructive pulmonary disease (COPD) patients received at least one PDC injection annually by general practitioners, which are the predominant prescribers. Of these patients, the majority received a single prescription. Regional differences were observed with particularly high prescription rates in western regions such as Rhineland\u2010Palatinate and Saarland. Monthly PDC prescription rates follow seasonal patterns of most common pollen allergens. Furthermore, over 23,000 patients with rhinopathy but without asthma or COPD received at least one prescription as well as approximately 3700 patients with chronic sinusitis with or without nasal polyps but no asthma or COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDCs continue to be administered to a relevant number of patients with asthma, COPD, and upper airway diseases despite clear guideline recommendations against systemic steroid treatment. The injection frequency, as well as the association with allergic comorbidities and seasonal patterns are compatible with the treatment of seasonal allergies. This underscores the need for targeted educational initiatives and stronger implementation of guideline\u2010adherent therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70187","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:59:59Z","timestamp":1783655999000},"source":"Crossref","is-referenced-by-count":0,"title":["Between Guidelines and Daily Practice: The Persistent Use of Parenteral Depot Corticosteroids in Germany"],"prefix":"10.1002","volume":"16","author":[{"given":"Christian","family":"Taube","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine University Hospital Essen\u2014Ruhrlandklinik  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Greulich","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Intensive Care, and Sleep Medicine Marburg University Member of the German Centre for Lung Research (DZL)  Marburg Germany"},{"name":"PneumoPraxis Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"B\u00f6ing","sequence":"additional","affiliation":[{"name":"Schwerpunktpraxis Lungen\u2010 und Bronchialheilkunde, Allergologie und Schlafmedizin  Meerbusch Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Pfaar","sequence":"additional","affiliation":[{"name":"Section of Rhinology and\u00a0Allergy Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Marburg Philipps\u2010Universit\u00e4t Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-0241","authenticated-orcid":false,"given":"Martin","family":"Wagenmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology D\u00fcsseldorf University Hospital (UKD)  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head\u00a0and Neck Surgery University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Sulk","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas J.","family":"Gerkau","sequence":"additional","affiliation":[{"name":"Respiratory and Immunology, BioPharmaceuticals Medical AstraZeneca GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Claudius","family":"Schwitalla","sequence":"additional","affiliation":[{"name":"Respiratory and Immunology, BioPharmaceuticals Medical AstraZeneca GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-4155","authenticated-orcid":false,"given":"Tim","family":"Vierbuchen","sequence":"additional","affiliation":[{"name":"Respiratory and Immunology, BioPharmaceuticals Medical AstraZeneca GmbH  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.09.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600672667"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/wox.0b013e3182758d80"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15007\u2010020\u20102615\u20101"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"66","article-title":"A Case of Fat Injection for Treating Subcutaneous Atrophy Caused by Local Administration of Corticosteroid","volume":"35","author":"Imagawa K.","year":"2010","journal-title":"Tokai Journal of Experimental and Clinical Medicine"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7302.1589"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629\u2010019\u201000110\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02331E"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601\u2010019\u20100303\u20106"},{"key":"e_1_2_11_12_1","unstructured":"M.Lommatzsch C.\u2010P.Cri\u00e9e C. 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