{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:17:17Z","timestamp":1787815037523,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic rhinitis, conjunctivitis and asthma are prevalent IgE\u2010mediated respiratory diseases that frequently coexist and impair quality of life. Allergen immunotherapy (AIT) has clinical benefits and potential disease\u2010modifying effects. Until recently, standardised definitions of disease control and remission were lacking in routine clinical practice, particularly for allergic rhinitis and conjunctivitis. This study aimed to propose preliminary definitions of control and remission in patients receiving AIT and to assess expert consensus using the Delphi methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scientific committee developed a survey based on a literature review and expert input, addressing symptoms, medication use, quality of life, exacerbations and tools for objective and subjective assessment. Forty allergists participated in a two\u2010round Delphi study. Consensus was predefined as \u2265\u00a070% agreement on a 9\u2010point Likert scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Consensus was achieved for all items after two rounds. The panel agreed on proposed definitions of disease control and clinical remission for allergic rhinitis, conjunctivitis and asthma in the context of AIT, integrating symptom severity, medication use, validated questionnaires and objective measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents preliminary expert\u2010consensus definitions of control and remission in allergic rhinitis, conjunctivitis and asthma in patients undergoing AIT. These definitions should not be interpreted as validated clinical criteria or endpoints. As a preliminary proposal, they aim to provide a structured approach for assessing treatment response in clinical practice by integrating symptom burden, medication use, patient\u2010reported outcomes and objective measures. They should be regarded as an initial conceptual step, and further prospective studies are needed to validate these criteria and confirm their relevance, feasibility and applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70191","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:20:40Z","timestamp":1785730840000},"source":"Crossref","is-referenced-by-count":0,"title":["Criteria for Control and Remission of Respiratory Allergic Disease With Allergen Immunotherapy: A Delphi Consensus"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-9273","authenticated-orcid":false,"given":"Elo\u00edna","family":"Gonz\u00e1lez\u2010Mancebo","sequence":"first","affiliation":[{"name":"Unidad de Alergolog\u00eda Hospital Universitario de Fuenlabrada  Madrid Spain"},{"name":"Immunotherapy Committee of the SEAIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-2321","authenticated-orcid":false,"given":"Juan Mar\u00eda","family":"Beitia Mazuecos","sequence":"additional","affiliation":[{"name":"Unidad de Alergolog\u00eda Hospital Universitario de Fuenlabrada  Madrid Spain"},{"name":"Immunotherapy Committee of the SEAIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-086X","authenticated-orcid":false,"given":"Ana I","family":"Tabar Purroy","sequence":"additional","affiliation":[{"name":"Immunotherapy Committee of the SEAIC  Madrid Spain"},{"name":"Servicio de Alergolog\u00eda Hospital Universitario de Navarra Instituto de Investigaci\u00f3n en Ciencias de la Salud (IDISNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9527-4244","authenticated-orcid":false,"given":"Mar","family":"Gandolfo\u2010Cano","sequence":"additional","affiliation":[{"name":"Servicio de Alergolog\u00eda Hospital Universitario La Paz  Madrid Spain"},{"name":"Asthma Committee of the SEAIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-5197","authenticated-orcid":false,"given":"Adriana","family":"Izquierdo\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Servicio de Alergolog\u00eda Hospital Universitario Consorci Sanitari de Terrasa Grupo de investigaci\u00f3n InOIA (investigaci\u00f3n en olfato, inmunolog\u00eda y alergia) Unidad Alergo\u2010Rino Teknon  Barcelona Spain"},{"name":"Allergic Rhinology and Conjunctivitis Committee of the SEAIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-2403","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Castillo Marchuet","sequence":"additional","affiliation":[{"name":"Immunotherapy Committee of the SEAIC  Madrid Spain"},{"name":"Consorci Sanitari de Terrasa  Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-1514","authenticated-orcid":false,"given":"Cristina Cuevas","family":"Bravo","sequence":"additional","affiliation":[{"name":"Immunotherapy Committee of the SEAIC  Madrid Spain"},{"name":"Servicio de Alergolog\u00eda Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Dom\u00ednguez","family":"Cereijo","sequence":"additional","affiliation":[{"name":"Immunotherapy Committee of the SEAIC  Madrid Spain"},{"name":"H. 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