{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:17:16Z","timestamp":1787815036117,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dupilumab is effective for moderate\u2010to\u2010severe atopic dermatitis (AD), but sustained disease control after treatment discontinuation remains challenging. House dust mite allergen immunotherapy (HDM\u2010AIT) may provide disease\u2010modifying effects in sensitized patients, but the added value of combining HDM\u2010AIT with dupilumab remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of dupilumab combined with HDM\u2010AIT versus dupilumab monotherapy in patients with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Web of Science, and Cochrane Library were searched from inception to April 21, 2026. Randomized controlled trials and comparative observational studies evaluating dupilumab plus HDM\u2010AIT versus dupilumab alone were included. Disease severity assessed by EASI or SCORAD was pooled using standardized mean differences (SMDs), Dermatology Life Quality Index (DLQI) using mean differences, and adverse events using risk ratios. Random\u2010effects models were applied. The certainty of evidence was assessed using the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four studies involving 138 patients were included, comprising one randomized controlled trial and three comparative observational studies. Combination therapy showed no significant improvement in disease severity at 6\u00a0months (SMD\u00a0=\u00a0\u22120.02, 95% CI \u22120.41 to 0.36;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00%) or 12\u00a0months (SMD\u00a0=\u00a00.53, 95% CI \u22121.10 to 2.16;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a093%). At 18\u00a0months, the pooled estimate suggested a possible benefit of combination therapy for disease severity, although the certainty of evidence was very low (SMD\u00a0=\u00a0\u22120.96, 95% CI \u22121.76 to \u22120.17;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a061%), although evidence was limited. At the follow\u2010up closest to 30\u00a0months, the effect favored combination therapy but was not significant (SMD\u00a0=\u00a0\u22121.16, 95% CI \u22122.56 to 0.24;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a087%). No significant differences were observed in DLQI, overall adverse events, or ocular adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence regarding dupilumab combined with HDM\u2010AIT for AD remains limited and inconclusive. Although an exploratory signal of improved disease severity was observed at 18\u00a0months, the available data did not demonstrate a statistically significant difference in adverse events, and the certainty of evidence was very low for all evaluated outcomes. Further adequately powered randomized controlled trials with standardized protocols, outcome definitions, and long\u2010term follow\u2010up are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70194","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:50:37Z","timestamp":1786215037000},"source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab Combined With House Dust Mite Allergen Immunotherapy for Atopic Dermatitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5984-5823","authenticated-orcid":false,"given":"Jiale","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Dermatology First Hospital of Shanxi Medical University  Taiyuan Shanxi China"},{"name":"The First Clinical Medical College Shanxi Medical University  Taiyuan Shanxi 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