{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:35Z","timestamp":1790337815175,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe asthma is a heterogeneous disease with variable clinical and inflammatory profiles that may influence responses to biological therapies. Identifying phenotypic clusters may help optimize patient selection and treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify phenotypic clusters (PCs) of patients with severe asthma treated with dupilumab and to assess differences in treatment response across clusters over a 12\u2010month period in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective study involving 140 adult patients with severe, poorly controlled T2\u2010asthma who received dupilumab as first\u2010line biological therapy for at least 12\u00a0months. Agglomerative clustering was applied to baseline clinical, laboratory, and functional parameters to identify PCs. Treatment response was assessed at 1, 6, and 12\u00a0months using ACT, ACQ\u20105, AQLQ, lung function (pre\u2010bronchodilator FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), T2\u2010biomarkers, and exacerbation rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three phenotypic clusters were identified. PC1 (early\u2010onset\u00a0allergic asthma with high IgE and severe atopic dermatitis) and PC3 (late\u2010onset mixed asthma with moderate IgE and persistent eosinophilia) showed rapid improvements in asthma control, lung function, and quality of life, with 71% and 75% of patients free from exacerbations, respectively. PC2 (predominantly non\u2010allergic, late\u2010onset, female\u2010dominant, with CRSwNP and NSAID hypersensitivity) demonstrated slower but progressive improvement, with 61.2% remaining exacerbation\u2010free after 12\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This retrospective real\u2010world study identified distinct phenotypic clusters of severe asthma with differential responses to dupilumab. Early identification of these phenotypes may help guide personalized asthma management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70198","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:04:16Z","timestamp":1789527856000},"source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic Clusters of Severe Asthma and Response to Dupilumab in Real\u2010World Practice"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-6637","authenticated-orcid":false,"given":"Daria S.","family":"Fomina","sequence":"first","affiliation":[{"name":"Moscow Clinical Research Center Hospital 52 of the Moscow Health Department  Moscow Russia"},{"name":"Federal State Autonomous Educational Institution of Higher Education \u201cI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)\u201d  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6655-3300","authenticated-orcid":false,"given":"Sergey V.","family":"Fedosenko","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution \u201cSiberian State Medical University\u201d of the Ministry of Health of the Russian Federation  Tomsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-387X","authenticated-orcid":false,"given":"\u0410nton \u0410.","family":"Chernov","sequence":"additional","affiliation":[{"name":"Moscow Clinical Research Center Hospital 52 of the Moscow Health Department  Moscow Russia"},{"name":"Federal State Budgetary Educational Institution of Postgraduate Education \u201cRussian Medical Academy of Continuous Professional Education\u201d of the Ministry of Health of the Russian Federation  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-5902","authenticated-orcid":false,"given":"Elena N.","family":"Bobrikova","sequence":"additional","affiliation":[{"name":"Moscow Clinical Research Center Hospital 52 of the Moscow Health Department  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3794-4991","authenticated-orcid":false,"given":"\u041elga \u0410.","family":"Mukhina","sequence":"additional","affiliation":[{"name":"Moscow Clinical Research Center Hospital 52 of the Moscow Health Department  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-4720","authenticated-orcid":false,"given":"Marina S.","family":"Lebedkina","sequence":"additional","affiliation":[{"name":"Moscow Clinical Research Center Hospital 52 of the Moscow Health Department  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-5424","authenticated-orcid":false,"given":"Alexander V.","family":"Karaulov","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Educational Institution of Higher Education \u201cI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)\u201d  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-3307","authenticated-orcid":false,"given":"Asel Yu.","family":"Nurtazina","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Educational Institution of Higher Education \u201cI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)\u201d  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-7975","authenticated-orcid":false,"given":"Mariana A.","family":"Lysenko","sequence":"additional","affiliation":[{"name":"Moscow Clinical Research Center Hospital 52 of the Moscow Health Department  Moscow Russia"},{"name":"Federal State Budgetary Educational Institution of Higher Education \u201cPirogov Russian National Research Medical University\u201d of the Ministry of Health of the Russian Federation  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0602-7215","authenticated-orcid":false,"given":"Harald","family":"Renz","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine and Pathobiochemistry Philipps University Marburg  Marburg 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