{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:58:05Z","timestamp":1790683085669,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational All"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Sesame allergy is associated with severe allergic reactions, low rates of spontaneous resolution, and significant psychosocial burden. Current management relies on strict avoidance and emergency treatment. Allergen\u2010specific immunotherapy, particularly oral immunotherapy (OIT), has emerged as a potential disease\u2010modifying approach, but evidence for sesame allergy remains limited. A systematic search was conducted through August 2025. Eligible studies included participants of any age with confirmed sesame allergy treated with allergen immunotherapy. Primary outcomes were desensitization and sustained unresponsiveness assessed by oral food challenge. Secondary outcomes included adverse events, epinephrine use, quality of life, and mortality. Risk of bias was evaluated using Joanna Briggs Institute tools. Nine studies met the inclusion criteria, including one study identified through citation searching. The evidence consisted, primarily small cohort studies and case series. Single\u2010allergen sesame OIT achieved high desensitization rates (approximately 85%\u201397%) across heterogeneous protocols and age groups. Sustained unresponsiveness was reported in a limited number of mainly pediatric cohorts. Most adverse events were mild to moderate; severe reactions requiring epinephrine were uncommon, and no deaths were reported. Adjunctive omalizumab improved tolerability in high\u2010risk adults. Sesame OIT shows promising efficacy with an acceptable safety profile in specialized settings. However, evidence is limited by small sample sizes, heterogeneity, and short follow\u2010up. Randomized controlled trials are needed to define optimal protocols and long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>The protocol for this systematic review was prospectively registered in PROSPERO (International Prospective Register of Systematic Reviews; Registration number: CRD420251087250)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70206","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:11:57Z","timestamp":1790680317000},"source":"Crossref","is-referenced-by-count":0,"title":["Sesame Immunotherapy: A Systematic Review and Narrative Synthesis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7391-5095","authenticated-orcid":false,"given":"Joanna","family":"Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-3863","authenticated-orcid":false,"given":"Katarzyna","family":"Kunkiel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4193-7584","authenticated-orcid":false,"given":"Anna","family":"Krupa\u2010\u0141aska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-4372","authenticated-orcid":false,"given":"Marek","family":"Kulus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-104X","authenticated-orcid":false,"given":"Katarzyna","family":"Grzela","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139058"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14001"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.9144"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.12.005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.10.031"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/jfa.2022.4.220003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.11.028"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.09.036"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399\u20103038.2003.00040.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.2005.00232.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103038.2006.00506.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1081\u20101206(10)60228\u20101"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.70022"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15902"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.09.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.11.031"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15863"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.08.006"},{"key":"e_1_2_12_20_1","volume-title":"Risk Assessment of Food Allergens. Part 1: Review and Validation of Codex Alimentarius Priority Allergen List Through Risk Assessment: Meeting Report","author":"World Health Organization","year":"2022"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.11124\/jbies\u201023\u201000268"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.11124\/jbies\u201022\u201000430"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.11124\/jbisrir\u2010d\u201019\u201000099"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2023.100171"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2025.01.036"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223\u2010017\u20100224\u20107"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.05.031"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2022.1730"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(17)30392\u20108"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2018.12.006"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100382"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223\u2010024\u201000915\u20106"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14350"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.05.007"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2025.03.001"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.03.002"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.12.001"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.03.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12268"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14132"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15211"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13211"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16345"}],"container-title":["Clinical and Translational Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clt2.70206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clt2.70206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clt2.70206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:12:00Z","timestamp":1790680320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clt2.70206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/clt2.70206"],"URL":"https:\/\/doi.org\/10.1002\/clt2.70206","archive":["Portico"],"relation":{},"ISSN":["2045-7022","2045-7022"],"issn-type":[{"value":"2045-7022","type":"print"},{"value":"2045-7022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"e70206"}}