{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:39:20Z","timestamp":1793194760431,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 115\u20102314\u2010B\u2010182\u2010034\u2010MY3"],"award-info":[{"award-number":["NSTC 115\u20102314\u2010B\u2010182\u2010034\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114\u20102321\u2010B\u2010182\u2010005"],"award-info":[{"award-number":["NSTC 114\u20102321\u2010B\u2010182\u2010005"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 111\u20102314\u2010B\u2010400\u2010040\u2010MY3"],"award-info":[{"award-number":["NSTC 111\u20102314\u2010B\u2010400\u2010040\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMPRG3M1381\u20103"],"award-info":[{"award-number":["CMPRG3M1381\u20103"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3L1111\u20103"],"award-info":[{"award-number":["CMRPG3L1111\u20103"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["OMRPG3Q0031"],"award-info":[{"award-number":["OMRPG3Q0031"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["PH\u2010114\u2010PP\u201008"],"award-info":[{"award-number":["PH\u2010114\u2010PP\u201008"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mitochondrial DNA copy number (mtDNA\u2010CN), a marker associated with mitochondrial function and cellular health, has been implicated in several chronic inflammatory diseases. Atopic dermatitis is a common chronic inflammatory skin disorder, yet the relationship between mtDNA\u2010CN and childhood atopic dermatitis remains unclear. This study aimed to investigate the association between mtDNA\u2010CN and atopic dermatitis in a population\u2010based cohort of school\u2010aged children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 1329 singleton children (56.4% boys; mean age\u00a0\u00b1\u00a0standard deviation: 6.5\u00a0\u00b1\u00a00.5\u00a0years) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort. Genomic DNA was extracted from peripheral blood, and mtDNA\u2010CN was quantified by real\u2010time quantitative polymerase chain reaction. Multivariable logistic regression models were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 1329 children, 328 (24.7%) children had physician\u2010diagnosed atopic dermatitis. Mean mtDNA\u2010CN was lower in children with atopic dermatitis than in those without (289.62\u00a0\u00b1\u00a0102.06 vs. 299.47\u00a0\u00b1\u00a091.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). Each one\u2010unit increase in log\u2010transformed mtDNA\u2010CN was associated with 28% lower odds of atopic dermatitis after adjustment for potential confounders (adjusted odds ratio: 0.72; 95% confidence interval: 0.54\u20130.96). Subgroup analyses showed that this inverse association was more pronounced among children breastfed for \u2265\u00a03\u00a0months and those with a birth weight \u2265\u00a02500\u00a0g.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides novel evidence of an inverse association between mtDNA\u2010CN and atopic dermatitis in children. Further longitudinal and mechanistic studies are warranted to confirm these findings and to evaluate the potential utility of mtDNA\u2010CN as a biomarker for atopic dermatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70214","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:54:27Z","timestamp":1791849267000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of Mitochondrial DNA Copy Number With Atopic Dermatitis in Children"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-4975","authenticated-orcid":false,"given":"Ju","family":"Chang\u2010Chien","sequence":"first","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"School of Medicine Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Han","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medical Education Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Public Health Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Life Science and Medicine National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences National Health Research Institutes  Zhunan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Szu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Chieh","family":"Meng","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-4972","authenticated-orcid":false,"given":"Ming\u2010Ling","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Microbiology and Immunology Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University  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