{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:39:11Z","timestamp":1793194751710,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational All"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      House dust mite (HDM)\u2010induced respiratory allergy is a major global health problem. Species distribution varies by region and climate;\n                      <jats:italic>Blomia tropicalis<\/jats:italic>\n                      is prevalent in tropical and subtropical areas and often coexists with\n                      <jats:italic>Dermatophagoides<\/jats:italic>\n                      spp. Although allergen immunotherapy (AIT) reduces symptoms and medication use, real\u2010world evidence for formulations including\n                      <jats:italic>B. tropicalis<\/jats:italic>\n                      remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the real\u2010world effectiveness and safety of triple\u2010mite subcutaneous immunotherapy (SCIT) with glutaraldehyde\u2010polymerized extracts of\n                      <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>\n                      ,\n                      <jats:italic>Dermatophagoides farinae<\/jats:italic>\n                      , and\n                      <jats:italic>B. tropicalis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical records of 208 patients (5\u201365\u00a0years) with mite\u2010induced allergic rhinoconjunctivitis, with or without asthma, sensitized to these mites were analyzed. All received \u2265\u00a012\u00a0months of SCIT. Follow\u2010up extended up to 5\u00a0years. Effectiveness was assessed annually using mixed models for repeated measures based on combined symptom and medication scores for rhinoconjunctivitis (RCSMS) and asthma (ACSMS), and individual symptom and medication scores. Safety was evaluated by recording adverse reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant and sustained improvements were observed. Adjusted LS\u2010mean RCSMS decreased from 3.97 at baseline to 2.26 at 1\u00a0year and 1.24 at 5\u00a0years (\u221243.1% and \u221268.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). ACSMS decreased from 2.74 to 1.36 and 0.46 (\u221250.5% and \u221283.3%). Symptom improvement was early and accompanied by progressive reductions in medication use. Safety was favourable, with one mild grade 1 systemic reaction (0.48% of patients; 0.015% per injection), resolving without treatment modification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Triple\u2010mite SCIT was associated with sustained, clinically meaningful reductions in symptoms and medication use, and showed a favourable safety profile, supporting a favourable benefit\u2013risk balance in regions where these mites coexist.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clt2.70217","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:37:11Z","timestamp":1791643031000},"source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Effectiveness and Safety of Triple\u2010Mite SCIT With\n                    <i>Dermatophagoides<\/i>\n                    and\n                    <i>Blomia tropicalis<\/i>"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-2296","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Garc\u00eda\u2010Robaina","sequence":"first","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gonz\u00e1lez\u2010Colino","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guacimara Lucia","family":"Hern\u00e1ndez\u2010Santana","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Rodr\u00edguez\u2010Plata","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-0303","authenticated-orcid":false,"given":"M\u00f3nica","family":"Gonz\u00e1lez\u2010Afonso","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-8262","authenticated-orcid":false,"given":"Ariel","family":"Callero","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Mart\u00ednez\u2010Tadeo","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Men\u00e9s","sequence":"additional","affiliation":[{"name":"Inmunotek, S.L.  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