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We biochemically characterized the CCD and CFTD causing actin mutants and show that all mutants fold correctly and are stable. Expression studies in fibroblasts, myoblasts, and myotubes show that these mutants incorporate in filamentous structures. However they do not intercalate between the nascent z\u2010lines in differentiating muscle cell cultures. We also show that the distribution of mitochondria and of the ryanodine receptors, and calcium release properties from ryanodine receptors, are unchanged in myotubes expressing the CCD causing mutants. CFTD causing mutants induce partly similar phenotypes as NM associated ones, such as rods and thickened actin fibers in cell culture. Our results suggest that molecular mechanisms behind CFTD and NM may be partly related. Cell Motil. Cytoskeleton, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cm.20340","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T18:25:34Z","timestamp":1234290334000},"page":"179-192","source":"Crossref","is-referenced-by-count":6,"title":["\u03b1\u2010Skeletal muscle actin mutants causing different congenital myopathies induce similar cytoskeletal defects in cell line 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