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In these proteins, small segments that are intrinsically disordered in their unbound native state can be functionally as important as identifiable folded units. These functional intrinsically disordered regions (IDRs) are however difficult to identify and characterize <jats:italic>in vitro<\/jats:italic>. Here, we try to summarize the state of the art in understanding the structural features and interfacial properties of IDRs involved in actin self\u2010assembly dynamics. Recent structural and functional insights into the regulation of widespread, multifunctional WH2\/\u03b2\u2010thymosin domains, and of other IDRs such as those associated with WASP\/WAVE, formin or capping proteins are examined. Understanding the functional versatility of IDRs in actin assembly requires apprehending by multiple structural and functional approaches their large conformational plasticity and dynamics in their interactions. In many modular ABPs, IDRs relay labile interactions with multiple partners and act as interaction hubs in interdomain and protein\u2013protein interfaces. They thus control multiple conformational transitions between the inactive and active states or between various active states of multidomain ABPs, and play an important role to coordinate the high turnover of interactions in actin self\u2010assembly dynamics. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cm.21140","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T09:28:40Z","timestamp":1378978120000},"page":"686-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Structural features and interfacial properties of WH2, \u03b2\u2010thymosin domains and other intrinsically disordered domains in the regulation of actin cytoskeleton dynamics"],"prefix":"10.1002","volume":"70","author":[{"given":"Louis","family":"Renault","sequence":"first","affiliation":[{"name":"Laboratoire d'Enzymologie et Biochimie Structurales Centre de Recherche de Gif, CNRS 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