{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:32:54Z","timestamp":1791142374355,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","award":["ANR A05135AS and ANR RPV07055ASA"],"award-info":[{"award-number":["ANR A05135AS and ANR RPV07055ASA"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytoskeleton"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>It remains a challenge to decode the molecular basis of the long\u2010term actin cytoskeleton rearrangements that are governed by the reprogramming of gene expression. <jats:italic>Bacillus anthracis<\/jats:italic> lethal toxin (LT) inhibits mitogen\u2010activated protein kinase (MAPK) signaling, thereby modulating gene expression, with major consequences for actin cytoskeleton organization and the loss of endothelial barrier function. Using a laser ablation approach, we characterized the contractile and tensile mechanical properties of LT\u2010induced stress fibers. These actin cables resist pulling forces that are transmitted at cell\u2013matrix interfaces and at cell\u2013cell discontinuous adherens junctions. We report that treating the cells with trichostatin A (TSA), a broad range inhibitor of histone deacetylases (HDACs), or with MS\u2010275, which targets HDAC1, 2 and 3, induces stress fibers. LT decreased the cellular levels of HDAC1, 2 and 3 and reduced the global HDAC activity in the nucleus. Both the LT and TSA treatments induced Rnd3 expression, which is required for the LT\u2010mediated induction of actin stress fibers. Furthermore, we reveal that treating the LT\u2010intoxicated cells with garcinol, an inhibitor of histone acetyl\u2010transferases (HATs), disrupts the stress fibers and limits the monolayer barrier dysfunctions. These data demonstrate the importance of modulating the flux of protein acetylation in order to control actin cytoskeleton organization and the endothelial cell monolayer barrier. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cm.21256","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T08:38:19Z","timestamp":1443170299000},"page":"542-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Contractile actin cables induced by <i>Bacillus anthracis<\/i> lethal toxin depend on the histone acetylation machinery"],"prefix":"10.1002","volume":"72","author":[{"given":"Monica","family":"Rolando","sequence":"first","affiliation":[{"name":"Microbial Toxins in Host\u2013Pathogen Interactions Equipe Labellis\u00e9e La Ligue Contre Le Cancer, INSERM, U1065, Centre M\u00e9diterran\u00e9en De M\u00e9decine Mol\u00e9culaire (C3M), 151 Route St Antoine de Ginesti\u00e8re, BP 2 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