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Tachyzoites, the fast dividing form of the parasite, divide by endodyogeny. This process involves a single round of DNA replication, closed nuclear mitosis, and assembly of two daughter cells within a mother. The successful completion of endodyogeny relies on the temporal and spatial coordination of a plethora of simultaneous events. It has been shown that the <jats:italic>Toxoplasma<\/jats:italic> centrosome serves as signaling hub which nucleates spindle microtubules during mitosis and organizes the scaffolding of daughter cells components during cytokinesis. In addition, the centrosome is essential for inheriting both the apicoplast (a chloroplast\u2010like organelle) and the Golgi apparatus. A growing body of evidence supports the notion that the <jats:italic>T. gondii<\/jats:italic> centrosome diverges in protein composition, structure and organization from its counterparts in higher eukaryotes making it an attractive source of potentially druggable targets. Here, we summarize the current knowledge on <jats:italic>T. gondii<\/jats:italic> centrosomal proteins and extend the putative centrosomal protein repertoire by <jats:italic>in silico<\/jats:italic> identification of mammalian centrosomal protein orthologs. We propose a working model for the organization and architecture of the centrosome in <jats:italic>Toxoplasma<\/jats:italic> parasites. Experimental validation of our proposed model will uncover how each predicted protein translates into the biology of centrosome, cytokinesis, karyokinesis, and organelle inheritance in <jats:italic>Toxoplasma<\/jats:italic> parasites.<\/jats:p>","DOI":"10.1002\/cm.21353","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T10:21:35Z","timestamp":1482834095000},"page":"55-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Towards a molecular architecture of the centrosome in <i>Toxoplasma gondii<\/i>"],"prefix":"10.1002","volume":"74","author":[{"given":"Juliette","family":"Morlon\u2010Guyot","sequence":"first","affiliation":[{"name":"Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235 CNRS, Universit\u00e9 Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Francia","sequence":"additional","affiliation":[{"name":"Molecular Biology Unit Institut Pasteur de Montevideo, Mataojo 2020 Montevideo 11400 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Dubremetz","sequence":"additional","affiliation":[{"name":"Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235 CNRS, Universit\u00e9 Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9026-5333","authenticated-orcid":false,"given":"Wassim","family":"Daher","sequence":"additional","affiliation":[{"name":"Dynamique des Interactions Membranaires Normales et Pathologiques, UMR5235 CNRS, Universit\u00e9 Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0461"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.07.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0453"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200808082"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.74"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12571"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-11-28"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.11.042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0452"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.01.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006741108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.064931"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2013.02.022"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/71350"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.123364"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E15-06-0437"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.06.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0370997"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-5-33"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00096-13"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.200900007"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4253-7_15"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(73)90063-4"},{"key":"e_1_2_10_29_1","first-page":"453","article-title":"L'ultrastructure du centriole et du centrocone chez la coccidie Eimeria necatrix. 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