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It is composed of SEPT12\u2010based septin core complex followed by assembling as octameric filament. In clinical examinations, mutations of <jats:italic>Septin12<\/jats:italic> result in male infertility, immotile sperm, as well as sperm with defective annuli. The dynamic assembly of septin filaments is regulated by several post\u2010translational modifications, including sumoylation, acetylation, and phosphorylation. Here, we briefly review the biological significance and the regulation of SEPT12 phosphorylation in the mammalian sperm physiology. During mammalian spermiogenesis, the phosphorylation of SEPT12 on Ser198 residue is important in regulating mammalian annulus architectures. SEPT12 phosphomimetic knock\u2010in mice displayed poor male fertility due to weak sperm motility and loss of the sperm annulus. SEPT12 is phosphorylated via Protein kinase A (PKA), and its phosphorylation interfered with SEPT12 polymerization into complexes and filaments. Taken together, the phosphorylation status of SEPT12 is crucial for its function in regulating the mammalian sperm physiology.<\/jats:p>","DOI":"10.1002\/cm.21491","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T16:36:34Z","timestamp":1535646994000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly"],"prefix":"10.1002","volume":"76","author":[{"given":"Chun\u2010Hsiang","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ru","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine, National Cheng Kung University  Tainan 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