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Conversely, in the peripheral nervous system (PNS), myelin is synthesized by a different cell type termed Schwann cells, and it remained unknown if septins also assemble as a multimer in PNS myelin. According to prior proteome analysis, PNS myelin comprises the subunits SEPTIN2, SEPTIN7, SEPTIN8, SEPTIN9, and SEPTIN11, which localize to the paranodal and abaxonal myelin subcompartments. Here, we use the\n                    <jats:italic>Cre<\/jats:italic>\n                    \/loxP\u2010system to delete the\n                    <jats:italic>Septin9<\/jats:italic>\n                    \u2010gene specifically in Schwann cells, causing a markedly reduced abundance of SEPTIN9 in sciatic nerves, implying that Schwann cells are the main cell type expressing SEPTIN9 in the nerve. However,\n                    <jats:italic>Septin9<\/jats:italic>\n                    \u2010deficiency in Schwann cells did not affect the abundance or localization of other septin subunits. In contrast, when deleting the\n                    <jats:italic>Septin2<\/jats:italic>\n                    \u2010gene in Schwann cells the abundance of all relevant septin subunits was markedly reduced, including SEPTIN9. Notably, we did not find evidence that deleting\n                    <jats:italic>Septin2<\/jats:italic>\n                    or\n                    <jats:italic>Septin9<\/jats:italic>\n                    in Schwann cells impairs myelin biogenesis, nerve conduction velocity or motor\/sensory capabilities, at least at the assessed timepoints. Our data thus show that SEPTIN2 but not SEPTIN9 is required for the formation or stabilization of a septin multimer in PNS myelin in vivo; however, its functional relevance remains to be established.\n                  <\/jats:p>","DOI":"10.1002\/cm.21736","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:33:33Z","timestamp":1668512013000},"page":"290-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeted inactivation of the\n                    <i>Septin2<\/i>\n                    and\n                    <i>Septin9<\/i>\n                    genes in myelinating Schwann cells of mice"],"prefix":"10.1002","volume":"80","author":[{"given":"Ann\u2010Kristin","family":"Martens","sequence":"first","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Erwig","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5976-9592","authenticated-orcid":false,"given":"Julia","family":"Patzig","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-7958","authenticated-orcid":false,"given":"Robert","family":"Fledrich","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst\u2010Martin","family":"F\u00fcchtbauer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-5738","authenticated-orcid":false,"given":"Hauke B.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-274"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490350107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201308068"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22379"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.10.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.765085"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072348"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2013-0247"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840209"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22561"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21643"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"Djannatian M. 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