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TNBC's aggressive nature and resistance to hormone\u2010based therapies heightens the risk of tumor progression and recurrence. Actin\u2010binding proteins, specifically WAVE3 from the Wiskott\u2013Aldrich syndrome protein (WASP) family, have emerged as major drivers in understanding TNBC biology. This review delves into the intricate molecular makeup of TNBC, shedding light on actin's fundamental role in cellular processes. Actin, a structural element in the cytoskeleton, regulates various cellular pathways essential for homeostasis. Its dynamic nature enables functions such as cell migration, motility, intracellular transport, cell division, and signal transduction. Actin\u2010binding proteins, including WAVE3, play pivotal roles in these processes. WAVE3, a member of the WASP family, remains the focus of this review due to its potential involvement in TNBC progression. While actin\u2010binding proteins are studied for their roles in healthy cellular cycles, their significance in TNBC remains underexplored. This review aims to discuss WAVE3's impact on TNBC, exploring its molecular makeup, functions, and significance in tumor progression. The intricate structure of WAVE3, featuring elements like the verprolin\u2013cofilin\u2013acidic domain and regulatory elements, plays a crucial role in regulating actin dynamics. Dysregulation of WAVE3 in TNBC has been linked to enhanced cell migration, invasion, extracellular matrix remodeling, epithelial\u2010mesenchymal transition, tumor proliferation, and therapeutic resistance. Understanding the role of actin\u2010binding proteins in cancer biology has potential clinical implications, making them potential prognostic biomarkers and promising therapeutic targets. The review emphasizes the need for further research into actin\u2010binding proteins' clinical applications, diagnostic value, and therapeutic interventions. In conclusion, this comprehensive review explores the complex interplay between actin and actin\u2010binding proteins, with special emphasis on WAVE3, in the context of TNBC. By unraveling the molecular intricacies, structural characteristics, and functional significance, the review paves the way for future research directions, clinical applications, and potential therapeutic strategies in the challenging landscape of TNBC.<\/jats:p>","DOI":"10.1002\/cm.21898","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T03:24:43Z","timestamp":1721273083000},"page":"130-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of\n                    <scp>WAVE3<\/scp>\n                    as an actin binding protein in the pathology of triple negative breast cancer"],"prefix":"10.1002","volume":"82","author":[{"given":"Kruyanshi","family":"Master","sequence":"first","affiliation":[{"name":"Department of Chemistry Cleveland State University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamyae","family":"El 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