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In\n                    <jats:italic>Xenopus<\/jats:italic>\n                    , depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left\u2013Right Organizer (LRO) exhibit multiple cilia per cell. Unexpectedly, we found that Ccdc11 is necessary for successful cytokinesis, explaining the multiciliation phenotype observed in Ccdc11\u2010depleted cells. The small GTPase RhoA is critical for cytokinesis, and our Ccdc11 depletion phenotypes are reminiscent of RhoA loss of function. Here, we demonstrate that during cytokinesis CCDC11 is localized to the cytokinetic contractile ring overlapping with RhoA, and CCDC11 regulates total RhoA protein levels. Our results connect CCDC11 to cytokinesis and LR patterning via RhoA regulation, providing a potential mechanism for heterotaxy disease pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/cm.21952","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:36:21Z","timestamp":1730356581000},"page":"360-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Heterotaxy Gene\n                    <i>CCDC11<\/i>\n                    Is Important for Cytokinesis via\n                    <scp>RhoA<\/scp>\n                    Regulation"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-6478","authenticated-orcid":false,"given":"Saurabh S.","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Biology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Amalraj","sequence":"additional","affiliation":[{"name":"Pediatric Genomics Discovery Program, Department of Pediatrics and Genetics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Arrigo","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Betleja","sequence":"additional","affiliation":[{"name":"Department of Medicine (Nephrology) Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Moresco","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John R.","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Scripps Research Institute  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe R.","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Department of Medicine (Nephrology) Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Cell Biology and Physiology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa K.","family":"Khokha","sequence":"additional","affiliation":[{"name":"Pediatric Genomics Discovery Program, Department of Pediatrics and Genetics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-00935-y"},{"issue":"605","key":"e_1_2_9_3_1","article-title":"MLL\/WDR5 Complex Regulates Kif2A Localization to Ensure Chromosome Congression and Proper Spindle Assembly During Mitosis","volume":"41","author":"Ali A.","year":"2017","journal-title":"Developmental 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