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Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2\/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore\u2010associated factor. This complex ensures proper kinetochore\u2010spindle attachment during male gametogenesis, likely by nucleating actin at the mitotic spindle. Disruption of Arp2\/3 function or actin polymerization leads to defective DNA segregation into gametes and developmental arrest of the parasite in the mosquito. Our findings reveal unexpected diversity in Arp2\/3 complex composition and function, highlighting specialized adaptations in malaria parasites and expanding our understanding of the Arp2\/3 complex and actin functions during mitosis. Here, we discuss some of the open questions that need to be addressed to fully understand the molecular mechanism of this unusual Arp2\/3 complex and its essential role in malaria transmission.<\/jats:p>","DOI":"10.1002\/cm.70030","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:52:53Z","timestamp":1755611573000},"page":"479-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of an Atypical Arp2\/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-0128","authenticated-orcid":false,"given":"Franziska","family":"Hentzschel","sequence":"first","affiliation":[{"name":"Integrative Parasitology, Centre for Infectious Diseases Heidelberg, University Medical Faculty  Heidelberg 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