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Defects in cilia are associated with various diseases, collectively known as ciliopathies. Although single\u2010cell transcriptomics and proteomics have identified many proteins linked to cilia, their physiological roles remain largely unclear. In this study, we identify coiled\u2010coil domain\u2010containing 89 (CCDC89) as a new ciliary protein. Super\u2010resolution imaging reveals that CCDC89 localizes to the axonemal lumen in motile cilia of mouse ependymal multiciliated cells. However, no apparent morphological abnormalities are observed in the lung and brain of\n                    <jats:italic>Ccdc89<\/jats:italic>\n                    knockout mice. While CCDC89 is highly abundant in the testis,\n                    <jats:italic>Ccdc89<\/jats:italic>\n                    knockout mice appear to have normal male fertility. Overall, our findings suggest that CCDC89 is dispensable for male fertility in mice, providing valuable information for other researchers to avoid unnecessary detailed studies.\n                  <\/jats:p>","DOI":"10.1002\/cm.70057","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:49:22Z","timestamp":1760176162000},"page":"652-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Cilia\u2010Associated Protein\n                    <scp>CCDC89<\/scp>\n                    Is Dispensable for Male Fertility in Mice"],"prefix":"10.1002","volume":"83","author":[{"given":"Dehao","family":"Song","sequence":"first","affiliation":[{"name":"Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences Shandong Normal University  Jinan 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