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Different models, based on cultured cardiomyocytes, were proposed for the last 30\u2009years to explain the sequence of events. These were then evaluated during heart development in embryos in\u00a0situ and more recently in cardiomyocytes that were derived from human induced pluripotent stem cells (iPSC\u2010CMs). A lot of the initial work was quite descriptive but recent advances in gene editing technology and in super resolution microscopy allow a more targeted functional analysis and will give unprecedented insight. This review will discuss the general principles of myofibril assembly in the heart and cover new findings on myofibril maintenance and turnover.<\/jats:p>","DOI":"10.1002\/cm.70187","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:29:53Z","timestamp":1787052593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assembly and Maintenance of Myofibrils in the Heart"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-5964","authenticated-orcid":false,"given":"Elisabeth","family":"Ehler","sequence":"first","affiliation":[{"name":"Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, British Heart Foundation Centre of Research Excellence, King's College London  London UK"},{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.yexcr.2007.01.009","article-title":"Re\u2010Expression of Proteins Involved in Cytokinesis During Cardiac Hypertrophy","volume":"313","author":"Ahuja P.","year":"2007","journal-title":"Experimental Cell Research"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1242\/jcs.01159","article-title":"Sequential Myofibrillar Breakdown Accompanies Mitotic Division of Mammalian Cardiomyocytes","volume":"117","author":"Ahuja P.","year":"2004","journal-title":"Journal of Cell Science"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.11.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05\u201012\u20101109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478\u2010811X\u201011\u201056"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.063859"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902312106"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.09.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010042222\u2010022728"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.70063"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"H1827","DOI":"10.1152\/ajpheart.00947.2002","article-title":"E\u2010Tmod Capping of Actin Filaments at the Slow\u2010Growing End Is Required to Establish Mouse Embryonic Circulation","volume":"284","author":"Chu X.","year":"2003","journal-title":"American Journal of Physiology. 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